Skip to content

EFFECTS OF ADRENALECTOMY ON THE GUT MICROBIOME AND HYPERTHERMIA INDUCED BY MDMA

Saodat Usanova

Eurasian Journal of Medical and Natural Sciences January 13, 2025 DOI: 10.70413/ejmns-v05-i01-s10733 (opens in new tab)

Relevant Not relevant

Study at a glance

AI-extracted from the abstract
Characteristics Animal experiment (preclinical study in adrenalectomized rats) Peer reviewed
Population Adrenalectomized (ADX) rats
Interventions MDMA Norepinephrine Corticosterone
Topics MDMA
Key findings The work investigates whether the gut-adrenal axis underlies MDMA-induced hyperthermia by testing acute supplementation with norepinephrine or corticosterone in adrenalectomized rats given MDMA. The text states the study's aim and design but reports no results or conclusions.

Abstract

The widespread use of the stimulant drug 3,4-methylenedioxymethamphetamine (MDMA), commonly referred to as Ecstasy, Molly, or X, has been associated with life-threatening hyperthermia in both humans and animal models. This study aimed to explore the role of the gut-adrenal axis in MDMA-induced hyperthermia by examining the effects of acute exogenous supplementation with norepinephrine (NE) or corticosterone (CORT) in adrenalectomized (ADX) rats following MDMA administration.

Comparable studies

Other preclinical and animal studies on MDMA, most cited first.

Study Year Design Participants
Neurotoxicity of the psychedelic amphetamine, methylenedioxymethamphetamine. Rats (implied by typical neurochemical study context) 1987 Experimental study
3,4-Methylenedioxymethamphetamine and 3,4-methylenedioxyamphetamine destroy serotonin terminals in rat brain: quantification of neurodegeneration by measurement of [3H]paroxetine-labeled serotonin uptake sites. Rat brain 1987 Animal experiment
Comparison of the monoamine transporters from human and mouse in their sensitivities to psychostimulant drugs Human and mouse dopamine, norepinephrine, and serotonin transporters expressed in cells 2006 In vitro laboratory study
Small Changes in Ambient Temperature Cause Large Changes in 3,4-Methylenedioxymethamphetamine (MDMA)-Induced Serotonin Neurotoxicity and Core Body Temperature in the Rat Rats 1998 Experimental study
Altered Serotonin Innervation Patterns in the Forebrain of Monkeys Treated with (±)3,4-Methylenedioxymethamphetamine Seven Years Previously: Factors Influencing Abnormal Recovery Squirrel monkeys treated with MDMA 1999 Observational cohort

Related reading

Explore topics

MDMA