Effect of the Preoperative Application of Esketamine on Stress Indicators in Paediatric Patients Undergoing Bronchoalveolar Lavage Under General Anaesthesia.
Jizheng Zhang, Jiaming Zheng, Xiaohua Sun, Yi Li, Wanlu Ren
British journal of hospital medicine (London, England : 2005) June 25, 2025 DOI: 10.12968/hmed.2025.0306 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Retrospective cohort study Peer reviewed |
|---|---|
| Sample size | 168 |
| Population | Children undergoing bronchoalveolar lavage under general anaesthesia at Tianjin Hospital of Tianjin University between February 2021 and January 2024 |
| Intervention | Esketamine |
| Topics | Esketamine |
| Keywords | Bronchoalveolar lavage General anaesthesia Preoperative period Serologic tests Pediatric anesthesia: children Pediatric patients Medical procedures Esketamine: esketamine Positive effect Reduce stress indicators Lower stress Enhancing well-being Recovery scores Clinical scales |
| Key findings | Preoperative esketamine significantly reduced postoperative stress indicators in pediatric patients undergoing bronchoalveolar lavage under general anaesthesia. |
Abstract
Aims/Background To explore the effect of the preoperative administration of esketamine on stress indices in paediatric patients undergoing bronchoalveolar lavage (BAL) under general anaesthesia.
Methods: A retrospective cohort study was conducted to collect clinical data from children undergoing BAL under general anaesthesia in Tianjin Hospital of Tianjin University between February 2021 and January 2024. The patients were divided into two groups: the reference group (taking no preoperative medications) and the study group (receiving preoperative esketamine). The baseline variables of the two groups were balanced using the 1:1 nearest neighbour matching method of propensity score matching (PSM), and the outcome indicators of the matched cohorts were compared.
Results: A total of 168 patients were included, including 86 in the reference group and 82 in the study group. After PSM, 46 cases in each group were successfully matched. Results showed that all postoperative stress indicators in the study group were significantly lower than those in the reference group (p 0.05).
Conclusion: The preoperative application of esketamine can reduce the stress response in paediatric patients undergoing BAL under general anaesthesia. This effect is beneficial for enhancing the outcome of surgical treatment.
Comparable studies
Other observational and cohort studies on esketamine, most cited first.
Citations in the library
Cites 3
- Efficacy of intravenous ketamine and intranasal esketamine with dose escalation for Major depression: A systematic review and meta-analysis. Journal of Affective Disorders July 1, 2024
- The 50% effective dose of remimazolam combined with different doses of esketamine for painless gastroscopy. Scientific Reports April 14, 2025
- Intravenous esketamine in pediatric Rett syndrome: An open-label, early phase 1 pilot study. Molecular therapy. Methods & clinical development March 13, 2025