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Behavioral effects of phencyclidine and its major metabolite, (trans)4-phenyl-4-(1-piperidinyl)cyclohexanol, in mice.

A Baba, T Yamamoto, N Kawai, H Yamamoto, T Suzuki, T Moroji

Behavioural Brain Research November 16, 1994 DOI: 10.1016/0166-4328(94)90075-2 (opens in new tab)

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AI-extracted from the abstract
Characteristics Animal behavioral study Peer reviewed
Population Mice
Interventions (trans)PPC PCP
Dose (trans)PPC 10 to 30 mg/kg; PCP 1 to 10 mg/kg
Key points (Trans)PPC (10–30 mg/kg) caused dose-related increases in locomotor activity and rearing without swaying or falling, whereas PCP (1–10 mg/kg) caused swaying and falling as well as hyperlocomotion. The authors propose that (trans)PPC may contribute, along with PCP, to PCP-induced psychotic reactions.

Abstract

To elucidate the biological activity of natural metabolites of phencyclidine (PCP), we examined the behavioral effects of a major metabolite, the trans isomer of 4-phenyl-4-(1-piperidinyl)cyclohexanol [(trans)PPC], in mice, (Trans)PPC caused dose-related increase in locomotor activity and rearing in mice when injected intraperitoneally at the doses ranging from 10 to 30 mg/kg. (Trans)PPC at any dose tested failed to produce swaying and falling. On the other hand, PCP at the doses ranging from 1 to 10 mg/kg caused swaying and falling as well as hyperlocomotion in a dose-related manner. These indicate that unlike PCP, hyperlocomotion and rearing may be the predominant behavioral responses to (trans)PPC in the 10-30 mg/kg dose range. Furthermore, it is feasible to surmise that not only PCP but also its major metabolite (trans)PPC is involved in psychotic reactions produced by PCP.

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