Effects of metaphit on phencyclidine and serotonin2 receptors.
Toshitaka Nabeshima, K Tohyama, A Noda, Y Maeda, M Hiramatsu, S M Harrer, T Kameyama, H Furukawa, A E Jacobson, K C Rice
Neuroscience Letters July 31, 1989 DOI: 10.1016/0304-3940(89)90096-7 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Peer reviewed |
|---|---|
| Population | Rats |
| Interventions | Metaphit Phencyclidine (PCP) 5-methoxy-N N-dimethyltryptamine |
| Dose | 1 micromole/rat |
| Duration | 24 hours after administration |
| Topics | Serotonin |
| Key points | Metaphit (1 micromole per rat) reduced the intensity of the PCP-induced head-twitch response and depleted both PCP and 5-HT2 receptors by 24 hours, but did not block 5-HT1A receptor-dependent behaviors induced by 5-methoxy-N,N-dimethyltryptamine. The authors state this reconfirms their hypothesis that PCP and 5-HT2 receptors may share very similar binding sites. |
Abstract
We have investigated whether metaphit, a derivative of phencyclidine (PCP) which irreversibly binds to a population of PCP receptor sites in rat brain, blocks PCP-induced head-twitch response which is produced through serotonin2 (5-HT2) receptors, and also whether metaphit decreases the capacity of 5-HT2 receptors. Metaphit (1 mumol/rat) had decreased the intensity of PCP-induced head-twitch response and had depleted both PCP and 5-HT2 receptors by 24 h after administration, but it failed to block 5-HT agonist 5-methoxy-N,N-dimethyltryptamine-induced 5-HT1A receptor-dependent behaviors. These results reconfirmed our hypothesis that PCP and 5-HT2 receptors may have very similar binding sites.
Citations in the library
Cites 3
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- Serotonergic involvement in phencyclidine-induced behaviors. Pharmacology, Biochemistry, and Behavior September 1984