Interactions of partial LSD analogs with behavioral disrupting effects of LSD and DMT in the rat.
B Kovacic, L J Wang Lu, D Ruffing, E F Domino
European Journal of Pharmacology January 1, 1978 DOI: 10.1016/0014-2999(78)90371-0 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Animal behavioral pharmacology experiment (preclinical) Peer reviewed |
|---|---|
| Population | Adult male Holtzman rats |
| Interventions | LSD DMT N N-diethylnipecotamide derivatives N-diethylbutyramide (DBA) 1-methyl-1 2 5 6-tetrahydropyridine-3-(N N-diethylcarboxamide) (THPC) |
| Dose | LSD 0.1 mg/kg; DMT 3.2 or 10 mg/kg; pretreatment compounds 5–40 mg/kg |
| Topics | DMT LSD |
| Key findings | LSD (0.1 mg/kg) and DMT (3.2 or 10 mg/kg) completely abolished FR4 bar-pressing for sweetened milk, with responding usually resuming within an hour at near control rates. Pretreatment with N,N-diethylnipecotamide derivatives, DBA, or THPC (5–40 mg/kg) either did not affect or prolonged the hallucinogen-induced suppression of bar-pressing; none shortened it. |
Abstract
Adult male Holtzman rats were trained to barpress on a schedule whereby every fourth press earned a reward of 0.01 ml of sugar-sweetened milk (FR4). After an i.p. injection of LSD (0.1 mg/kg) or DMT (3.2 or 10 mg/kg) such barpressing is abolished completely and resumed, usually within an hour, at a rate near the preinjection control rate of pressing. It continues at a steady, uninterrupted pace until the animals are removed from the operant chamber one-half hour later. A series of N,N-diethylnipecotamide derivatives were synthesized and tested for their ability to modify the disruptive effect of these hallucinogens. N,N-diethylbutyramide (DBA) and 1-methyl-1,2,5,6-tetrahydropyridine-3-(N,N-diethylcarboxamide) (THPC) were also tested. Pretreatment with a single i.p. injection of any of these compounds (5--40 mg/kg) either had no effect on or else prolonged the duration of hallucinogen-induced cessation of barpressing.
Comparable studies
Other preclinical and animal studies on DMT, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| The Hallucinogen N,N -Dimethyltryptamine (DMT) Is an Endogenous Sigma-1 Receptor Regulator Mice and cell lines | 2009 | Experimental study | |
| Correlation between the potency of hallucinogens in the mouse head-twitch response assay and their behavioral and subjective effects in other species. C57BL/6J mice | 2020 | Experimental study with dose-response experiments | |
| Psychedelic N,N-dimethyltryptamine and 5-methoxy-N,N-dimethyltryptamine modulate innate and adaptive inflammatory responses through the sigma-1 receptor of human monocyte-derived dendritic cells. Human primary monocyte-derived dendritic cells | 2014 | In vitro study | |
| Inhibitory effect of chlorpromazine on the syndrome of hyperactivity produced by l‐tryptophan or 5‐methoxy‐N,N‐dimethyltryptamine in rats treated with a monoamine oxidase inhibitor Rats | 1971 | Experimental study | |
| Effects of N,N-Dimethyltryptamine on Rat Behaviors Relevant to Anxiety and Depression Adult male Sprague-Dawley rats | 2018 | Experimental study |
Citations in the library
Cited by 5
- Simple Analogs of the LSD D-Ring: A Consideration of Structure-Activity Relationships and Their Potential as Therapeutics. ACS Chemical Neuroscience November 5, 2025
- Comparison of the discriminative stimulus effects of dimethyltryptamine with different classes of psychoactive compounds in rats Psychopharmacology July 1, 2009
- Opioid-hallucinogen interactions. Pharmacology, Biochemistry, and Behavior February 1986
- Effects of selected opioid agonists and antagonists on DMT- and LSD-25-induced disruption of food-rewarded bar pressing behavior in the rat. Psychopharmacology 1981
- Naloxone enhancement of DMT and LSD-25 induced suppression of food-rewarded bar pressing behavior in the rat. Psychopharmacology April 25, 1979
Cites 4
- Steric and Electronic Relationships among Some Hallucinogenic Compounds Proceedings of the National Academy of Sciences September 1, 1970
- Dimethyltryptamine Experiments with Psychotics Journal of Mental Science April 1, 1958
- Tolerance and limited cross-tolerance to the effects of N, N-dimethyltryptamine (DMT) and lysergic acid diethylamide-25 (LSD) on food-rewarded bar pressing in the rat. Journal of Pharmacology and Experimental Therapeutics June 1, 1976
- Behavioural Effects of some Derivatives of Amphetamine and LSD and their Significance Nature May 16, 1970