Temporal dynamics of spontaneous MEG activity in brain networks.
Francesco De Pasquale, Stefania Della Penna, Abraham Z. Snyder, Christopher Lewis, Dante Mantini, Laura Marzetti, Paolo Belardinelli, Luca Ciancetta, Vittorio Pizzella, Gian Luca Romani, Maurizio Corbetta
Proceedings of the National Academy of Sciences of the United States of America March 16, 2010 DOI: 10.1073/pnas.0913863107 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Observational neuroimaging study Peer reviewed |
|---|---|
| Duration | 5 min epochs |
| Keywords | Brain Nerve net Humans Oxygen Imaging, three-dimensional Magnetic resonance imaging Magnetoencephalography Attention Models, neurological Female Young adult |
| Key findings | MEG shows correlates of the dorsal attention and default mode resting-state networks, with 5-minute epoch maps resembling fMRI but limited to the seed hemisphere. Accounting for nonstationarity revealed transient, more complete networks spanning both hemispheres. These networks manifest as synchronous power modulation mainly in theta, alpha, and beta bands, slower than local event-related BOLD correlates. |
Abstract
Functional MRI (fMRI) studies have shown that low-frequency (<0.1 Hz) spontaneous fluctuations of the blood oxygenation level dependent (BOLD) signal during restful wakefulness are coherent within distributed large-scale cortical and subcortical networks (resting state networks, RSNs). The neuronal mechanisms underlying RSNs remain poorly understood. Here, we describe magnetoencephalographic correspondents of two well-characterized RSNs: the dorsal attention and the default mode networks. Seed-based correlation mapping was performed using time-dependent MEG power reconstructed at each voxel within the brain. The topography of RSNs computed on the basis of extended (5 min) epochs was similar to that observed with fMRI but confined to the same hemisphere as the seed region. Analyses taking into account the nonstationarity of MEG activity showed transient formation of more complete RSNs, including nodes in the contralateral hemisphere. Spectral analysis indicated that RSNs manifest in MEG as synchronous modulation of band-limited power primarily within the theta, alpha, and beta bands-that is, in frequencies slower than those associated with the local electrophysiological correlates of event-related BOLD responses.
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