Bufobutanoic Acid and Bufopyramide, Two New Indole Alkaloids from the Chinese Traditional Drug Ch'an Su
Yoshiaki Kamano, Hiroshi Morita, Rui Takano, Ayano Kotake, Toshihiko Nogawa, Hirohumi Hashima, Koichi Takeya, Hideji Itokawa, George R. Pettit
Heterocycles 1999 DOI: 10.3987/com-98-s(h)55 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Laboratory study (natural product isolation and structure elucidation) Peer reviewed |
|---|---|
| Population | Murine P388 lymphocytic leukemia cells |
| Interventions | Bufobutanoic acid Bufopyramide |
| Measures | IC50 |
| Citations | 24 |
| Key points | Two new indole alkaloids, bufobutanoic acid and bufopyramide, were isolated from Ch'an Su and structurally characterized. Both showed cytotoxicity against murine P388 lymphocytic leukemia cells, with IC50 values of 22 µg/mL and 7.6 µg/mL respectively, so bufopyramide was the more potent compound in this assay. |
Abstract
Two new bioactive indole alkaloids, 5-hydroxytryptamine (serotonin) N-4-oxobutanoic acid and 5-hydroxytryptamine N-acetyl-N-pyrrolecarboxarnide , named as bufobutanoic acid (2) and bufopyramide (3), respectively, were isolated from the Chinese traditional drug Ch'an Su in addition to known bufotenine (1).The structures were elucidated on the basis of spectroscopic data.Bufobutanoic acid (2) and bufopyramide (3) exhibited cytotoxicity against murine P388 lymphocytic leukemia cells with IC50 values of 22 &nL and 7.6 vgimL, respectively.