2,5-Dimethylbufotenine and 2,5-dimethylbufotenidine: novel derivatives of natural tryptamines found in Bufo alvarius toads
Duyen N. K. Pham, Andrew R Chadeayne, James A. Golen, David R. Manke
Acta Crystallographica Section E Crystallographic Communications January 29, 2021 DOI: 10.1107/s2056989021000803 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Crystallographic study Peer reviewed |
|---|---|
| Topics | 5-MeO-DMT |
| Keywords | Hydrogen bond Hydrate Methyl iodide Medicinal chemistry Molecule Stereochemistry Tryptamines Ion Crystallography Inorganic chemistry Alkaloids |
| Citations | 7 |
| Key points | The three tryptamine derivatives form distinct hydrogen-bond networks and π–π interactions in their crystal structures. |
Abstract
The solid-state structure of the bufotenine derivative bis(5-methoxy-2, N , N -trimethyltryptammonium) (5-MeO-2-Me-DMT) fumarate (systematic name: bis{[2-(5-methoxy-2-methyl-1 H -indol-3-yl)ethyl]dimethylazanium} (2 E )-but-2-enedioate), 2C 14 H 21 N 2 O + ·C 4 H 2 O 4 2− , the bufotenidine derivative 5-methoxy-2, N , N , N -tetramethyltryptammonium (5-MeO-2-Me-TMT) iodide {systematic name: [2-(5-methoxy-2-methyl-1 H -indol-3-yl)ethyl]trimethylazanium iodide}, C 15 H 23 N 2 O + ·I − , and the hydrate of the same {systematic name: [2-(5-methoxy-2-methyl-1 H -indol-3-yl)ethyl]trimethylazanium iodide monohydrate}, C 15 H 23 N 2 O + ·I − ·H 2 O, are reported. The structure of 5-MeO-2-Me-DMT fumarate possesses one tryptammonium cation and a half of a fumarate dianion in the asymmetric unit, linked together by N—H...O hydrogen bonds in infinite two-dimensional networks parallel to the (101) plane. The structure of 5-MeO-2-Me-TMT iodide possesses one tryptammonium cation and one iodide anion in the asymmetric unit. The ions are linked via N—H...I hydrogen bonds, and indoles are coupled in dimers through π–π interactions. The hydrate of 5-MeO-2-Me-TMT iodide possesses one tryptammonium cation, one iodide anion and one water molecule in the asymmetric unit. It shows N—H...I and O—H...I hydrogen bonds that couple the tryptammonium cations into dimers.