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Acceptance and Commitment Therapy for Co-Occurring Posttraumatic Stress Disorder and Alcohol Use Disorders in Veterans: Pilot Treatment Outcomes.

Eric C Meyer, Robyn D. Walser, Barbara Hermann, Heidi La Bash, Bryann B DeBeer, Sandra B Morissette, Nathan A Kimbrel, Oi-Man Kwok, Sonja V Batten, Paula P. Schnurr

Journal of Traumatic Stress October 19, 2018 DOI: 10.1002/jts.22322 (opens in new tab)

Study at a glance

AI-extracted from the abstract
Characteristics Uncontrolled pilot study Peer reviewed
Sample size 43
Population Veterans with co-occurring PTSD and alcohol use disorder
Intervention Acceptance and Commitment Therapy (ACT)
Duration 12-session outpatient individual therapy protocol; 3-month follow-up
Topics Meditation Addiction PTSD
Keywords Humans Alcoholism Treatment outcome Cohort studies Pilot projects Stress disorders, post-traumatic Quality of life Veterans Female
Key points Among 43 veterans with co-occurring PTSD and AUD, an uncontrolled 12-session ACT protocol was associated with reductions in PTSD and alcohol-related symptoms at posttreatment that largely persisted at 3-month follow-up, along with higher quality of life and fewer depressive symptoms. The authors report that improvements were associated with more between-session mindfulness practice and reductions in experiential avoidance and psychological inflexibility, consistent with the ACT model.

Abstract

Posttraumatic stress disorder (PTSD) and alcohol use disorder (AUD) frequently co-occur and are associated with worse outcomes together than either disorder alone. A lack of consensus regarding recommendations for treating PTSD-AUD exists, and treatment dropout is a persistent problem. Acceptance and Commitment Therapy (ACT), a transdiagnostic, mindfulness- and acceptance-based form of behavior therapy, has potential as a treatment option for PTSD-AUD. In this uncontrolled pilot study, we examined ACT for PTSD-AUD in 43 veterans; 29 (67%) completed the outpatient individual therapy protocol (i.e., ≥ 10 of 12 sessions). Clinician-assessed and self-reported PTSD symptoms were reduced at posttreatment, ds = 0.79 and 0.96, respectively. Self-reported symptoms of PTSD remained lower at 3-month follow-up, d = 0.88. There were reductions on all alcohol-related outcomes (clinician-assessed and self-reported symptoms, total drinks, and heavy drinking days) at posttreatment and 3-month follow-up, dmean = 0.91 (d range: 0.65-1.30). Quality of life increased at posttreatment and follow-up, ds = 0.55-0.56. Functional disability improved marginally at posttreatment, d = 0.35; this effect became significant by follow-up, d = 0.52. Fewer depressive symptoms were reported at posttreatment, d = 0.50, and follow-up, d = 0.44. Individuals experiencing suicidal ideation reported significant reductions by follow-up. Consistent with the ACT theoretical model, these improvements were associated with more between-session mindfulness practice and reductions in experiential avoidance and psychological inflexibility. Recommendations for adapting ACT to address PTSD-AUD include assigning frequent between-session mindfulness practice and initiating values clarification work and values-based behavior assignments early in treatment.

Comparable studies

Other non-randomized and open-label trials on PTSD, most cited first.

Study Year Design Participants
Durability of improvement in post-traumatic stress disorder symptoms and absence of harmful effects or drug dependency after 3,4-methylenedioxymethamphetamine-assisted psychotherapy: a prospective long-term follow-up study. Adults with chronic, treatment-resistant PTSD 2013 Long-term follow-up of a completed trial n = 19
Loving‐Kindness Meditation for Posttraumatic Stress Disorder: A Pilot Study Veterans with posttraumatic stress disorder (PTSD) 2013 Open pilot trial
Effects of Transcendental Meditation in Veterans of Operation Enduring Freedom and Operation Iraqi Freedom With Posttraumatic Stress Disorder: A Pilot Study Veterans from Operation Enduring Freedom or Operation Iraqi Freedom with combat-related... 2011 Uncontrolled pilot study n = 5
MDMA-facilitated cognitive-behavioural conjoint therapy for posttraumatic stress disorder: an uncontrolled trial. Couples in which one partner was diagnosed with PTSD 2020 Pilot study n = 6
Culturally informed research design issues in a study for MDMA-assisted psychotherapy for posttraumatic stress disorder People of color with posttraumatic stress disorder 2019 Phase 2 open-label multisite study

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