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Mechanisms of change in acceptance and commitment therapy : the role of self-compassion, mindfulness, and anxiety sensitivity in simple and multiple mediation

Amanda R. Russo

2013 DOI: 10.54014/g6cj-gjnm (opens in new tab)

Study at a glance

AI-extracted from the abstract
Characteristics Randomized clinical trial with mediation analysis
Sample size 208
Population Online sample of individuals who self-reported suffering from anxiety
Duration Three-month treatment period
Topics Anxiety Meditation
Key findings Self-compassion, mindfulness, and anxiety sensitivity each singly mediated the relation between treatment group and PTSD- and depression-related symptoms, and the three together mediated this relation in multiple mediation models. The ACT workbook condition led to better outcomes via these mediators. Anxiety sensitivity was a specific indirect effect for PTSD symptoms; self-compassion (most important) and anxiety sensitivity (second most important) were specific indirect effects for depression symptoms.

Abstract

Much of psychotherapy research over the past few decades has focused explicitly on outcomes and neglected examining mediators or mechanisms of change. Not surprisingly, an abundance of outcome research focuses on Acceptance and Commitment Therapy (ACT). Nevertheless, very few studies have examined ACT processes in formal mediation analyses. Three potential mediators of outcomes in ACT include self-compassion, mindfulness, and anxiety sensitivity. The current experiment extends an original evaluation of the effectiveness of two self-help workbooks (traditional Cognitive Behavioral Therapy--CBT--and ACT) for the treatment of anxious suffering in a randomized clinical trial, examining potential simple and multiple mediators responsible for the change in posttraumatic stress disorder- (PTSD) and depression-related symptoms. Participants included an online sample of individuals who self-reported suffering from anxiety. Participants (n = 208) were randomized to one of the two treatment groups and instructed to work through (with no therapeutic guidance) their respective workbooks over the three-month treatment period. Only participants who completed both the pre- and post-treatment assessment batteries (n = 67) were included in the mediation analyses. Each of the three processes (self-compassion, mindfulness, and anxiety sensitivity) singly (simple mediation) mediated the relation between treatment group (CBT or ACT workbook condition) and outcomes (PTSD- and depression-related symptoms). For both PTSD- and depression-related symptoms, the group of mediators as a whole (multiple mediation) mediated the relation between treatment group and outcome. The ACT workbook condition led to better outcomes via the proposed mediators in both the simple and multiple mediation models. In the multiple mediation model of PTSD-related symptoms, anxiety sensitivity emerged as a specific indirect effect, whereas in the multiple mediation model of depression-related symptoms, self-compassion (most important) and anxiety sensitivity (second most important) emerged as specific indirect effects. Self-compassion, mindfulness, and anxiety sensitivity appear to be important mediators of the ACT workbook relative to the CBT workbook. In particular, anxiety sensitivity and self-compassion appear to hold special importance among processes presented in the ACT workbook.

Comparable studies

Other randomized controlled trials on anxiety, most cited first.

Study Year Design Participants
Prevention of relapse/recurrence in major depression by mindfulness-based cognitive therapy. Recovered recurrently depressed patients 2000 Randomized controlled trial n = 145
Psilocybin produces substantial and sustained decreases in depression and anxiety in patients with life-threatening cancer: A randomized double-blind trial Cancer patients with life-threatening diagnoses and symptoms of depression and/or anxiety 2016 Randomized controlled trial n = 51
Rapid and sustained symptom reduction following psilocybin treatment for anxiety and depression in patients with life-threatening cancer: a randomized controlled trial Patients with cancer-related anxiety and depression 2016 Double-blind, placebo-controlled, crossover trial n = 29
Psilocybin can occasion mystical-type experiences having substantial and sustained personal meaning and spiritual significance Hallucinogen-naïve adults reporting regular participation in religious or spiritual... 2006 Double-blind study n = 36
Pilot Study of Psilocybin Treatment for Anxiety in Patients With Advanced-Stage Cancer Adults with advanced-stage cancer and anxiety 2010 Double-blind, placebo-controlled study n = 12

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