Investigating novel pharmacological strategies for treatment-resistant depression: focus on new mechanisms and approaches
Aline Silva de Miranda, Eliana C B Toscano, Venugopal Reddy Venna, Frederico Guilherme Graeff, Antonio Lucio Teixeira
Expert Opinion on Drug Discovery January 31, 2025 DOI: 10.1080/17460441.2025.2460674 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Review Peer reviewed |
|---|---|
| Interventions | Esketamine psilocybin buprenorphine |
| Topics | Ketamine Psilocybin Depression |
| Keywords | Treatment-resistant depression trd Refractory depression Buprenorphine Treatment resistant depression Novel therapies Psychedelics ketamine Hal Depression major depression Clinical depression |
| Citations | 2 |
| Key findings | Omics approaches may reveal glial-mediated mechanisms as therapeutic targets in treatment-resistant depression. |
Abstract
The understanding of the multiple pathophysiological mechanisms involved in TRD may add further value to the effective treatment, contributing to a more personalized approach. Esketamine was approved for the treatment of TRD and novel drugs with rapid antidepressant actions such as psilocybin and buprenorphine have also been investigated as potential therapeutic strategies. Over the past decades, technological advances such as omics approaches have broadened our knowledge regarding molecular and genetic underpinnings of complex conditions like TRD. Omics approaches could open new avenues for investigating glial-mediated mechanisms, including their crosstalk with neurons, as therapeutic targets in TRD.
Comparable studies
Other narrative reviews on psilocybin for depression, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Classic psychedelics: An integrative review of epidemiology, therapeutics, mystical experience, and brain network function. General population | 2019 | Integrative review | |
| Molecular Mechanisms of Psilocybin and Implications for the Treatment of Depression | 2021 | Review | |
| Registered clinical studies investigating psychedelic drugs for psychiatric disorders. Registered clinical trials on clinicaltrials.gov evaluating psychedelics for... | 2021 | Review | n = 70 |
| Depression, Mindfulness, and Psilocybin: Possible Complementary Effects of Mindfulness Meditation and Psilocybin in the Treatment of Depression. A Review | 2020 | Review | |
| From psychiatry to neurology: Psychedelics as prospective therapeutics for neurodegenerative disorders | 2021 | Review |