Psychedelics for Brain Injury: A Mini-Review.
Mia Khan, Gregory Carter, Sunil K Aggarwal, Julie Holland
Front Neurol July 29, 2021 DOI: 10.3389/fneur.2021.685085 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Narrative mini-review Case report Peer reviewed |
|---|---|
| Topics | Neuroplasticity |
| Keywords | Psychedelics. Psychedelic compounds Psychoactive substances Hallucinogens Brain injury. Neurological damage Head trauma Tbi Neuroplasticity. Cognitive enhancement Therapeutic potential. Medical applications Clinical use Treatment Therapy |
| Citations | 33 |
| Key findings | Psychedelic pharmacotherapies may influence future brain injury treatment through modulation of neuroinflammation, hippocampal neurogenesis, neuroplasticity, and brain complexity. |
Abstract
Objective: Stroke and traumatic brain injury (TBI) are among the leading causes of disability. Even after engaging in rehabilitation, nearly half of patients with severe TBI requiring hospitalization are left with major disability. Despite decades of investigation, pharmacologic treatment of brain injury is still a field in its infancy. Recent clinical trials have begun into the use of psychedelic therapeutics for treatment of brain injury. This brief review aims to summarize the current state of the science's relevance to neurorehabilitation, and may act as a resource for those seeking to understand the precedence for these ongoing clinical trials.
Methods: Narrative mini-review of studies published related to psychedelic therapeutics and brain injury.
Results: Recent in vitro, in vivo , and case report studies suggest psychedelic pharmacotherapies may influence the future of brain injury treatment through modulation of neuroinflammation, hippocampal neurogenesis, neuroplasticity, and brain complexity.
Conclusions: Historical data on the safety of some of these substances could serve in effect as phase 0 and phase I studies. Further phase II trials will illuminate how these drugs may treat brain injury, particularly TBI and reperfusion injury from stroke.