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Nitrous oxide inhalation-induced cerebral venous sinus thrombosis in a 20-year-old man: A case report

Cheng Peng, Xi Liu, Kongyuan Wu, H. Lang, Li He, N. Chen

Heliyon February 1, 2023 DOI: 10.1016/j.heliyon.2023.e13473 (opens in new tab)

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Study at a glance

AI-extracted from the abstract
Characteristics Case study Case report Peer reviewed
Sample size 1
Population A young person with probable nitrous oxide abuse
Key findings The authors report a case of probable nitrous oxide abuse-related cerebral venous sinus thrombosis in a young person who, they state, had no common confounding risk factors for thrombosis other than nitrous oxide. They present this as a rarely reported manifestation of nitrous oxide abuse, which has been linked to neuropathy, myelopathy, encephalopathy, and thrombosis at other sites.

Abstract

Nitrous oxide is increasingly abused in the young population and has been verified to induce neuropathy, myelopathy, encephalopathy, and thrombosis. Nitrous oxide-related thrombosis was identified in the coronary artery, ascending aorta, pulmonary artery, and deep vein in the lower extremities. Cases with nitrous oxide abuse-related thrombosis in cerebral veins or cerebral venous sinus have rarely been reported, and confounding risk factors for thrombosis other than nitrous oxide exist in previous cases. Here, we report a case of probable nitrous oxide abuse-related cerebral venous sinus thrombosis without common confounding risk factors for thrombosis except for nitrous oxide.

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