Ketamine Cystitis in a Female Patient on Short-term Ketamine Therapy for Treatment Resistant Depression: Case Report (Preprint)
Study at a glance
AI-extracted from the abstract| Characteristics | Case report |
|---|---|
| Intervention | Ketamine |
| Topics | Depression Esketamine Ketamine |
| Key points | The authors report that ketamine-induced ulcerative cystitis, which causes lower urinary tract symptoms and upper renal tract damage in over 25% of regular recreational users, has not been reported in therapeutic ketamine use for depression. They state that the exact pathogenesis is unknown, complicating treatment and prevention. |
Abstract
Ketamine has been shown to be a novel and exciting antidepressant medication in patients with treatment-resistant depression. A complication commonly seen in frequent and heavy recreational use of ketamine is ulcerative cystitis, which presents with lower urinary tract symptoms (LUTS) and upper renal tract damage, seen in over 25% of regular users (3, 4). Although KIC is a recognised complication in recreational use of ketamine, its occurrence in therapeutic use for depression has so far not been reported. The exact pathogenesis of ketamine induced cystitis is currently unknown, making treatment and prevention much more difficult.
Citations in the library
Cites 4
- A Randomized Trial of an N-methyl-D-aspartate Antagonist in Treatment-Resistant Major Depression Archives of General Psychiatry August 1, 2006
- Efficacy and Safety of Flexibly Dosed Esketamine Nasal Spray Combined With a Newly Initiated Oral Antidepressant in Treatment-Resistant Depression: A Randomized Double-Blind Active-Controlled Study American Journal of Psychiatry May 21, 2019
- Comparative efficacy of racemic ketamine and esketamine for depression: a systematic review and meta-analysis Journal of Affective Disorders September 23, 2020
- Ketamine-Induced Cystitis: A Comprehensive Review of the Urologic Effects of This Psychoactive Drug. Health Psychology Research September 15, 2022