Electrical stimulation of the human brain: perceptual and behavioral phenomena reported in the old and new literature.
Aslihan Selimbeyoglu, Josef Parvizi
Frontiers in Human Neuroscience May 31, 2010 DOI: 10.3389/fnhum.2010.00046 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Review Peer reviewed |
|---|---|
| Population | Awake and conscious human subjects undergoing electrical brain stimulation, including healthy subjects and patients with psychosis or epilepsy |
| Intervention | Electrical brain stimulation |
| Keywords | Behavior Cognition Neuromodulation Neurostimulation Intracranial electrophysiology Human brain mapping |
| Key findings | The review argues that electrical brain stimulation studies provide information about the neural correlates of cognition and behavior in healthy humans and about the neuroanatomy of illusions and hallucinations in psychosis and symptomatogenic zones in epilepsy. The authors propose that modulation of activity within a localized but distributed neuroanatomical network may explain the perceptual and behavioral phenomena reported during focal electrical stimulation of the human brain. |
Abstract
In this review, we summarize the subjective experiential phenomena and behavioral changes that are caused by electrical stimulation of the cerebral cortex or subcortical nuclei in awake and conscious human subjects. Our comprehensive review contains a detailed summary of the data obtained from electrical brain stimulation (EBS) in humans in the last 100 years. Findings from the EBS studies may provide an additional layer of information about the neural correlates of cognition and behavior in healthy human subjects, or the neuroanatomy of illusions and hallucinations in patients with psychosis and the brain symptomatogenic zones in patients with epilepsy. We discuss some fundamental concepts, issues, and remaining questions that have defined the field of EBS, and review the current state of knowledge about the mechanism of action of EBS suggesting that the modulation of activity within a localized, but distributed, neuroanatomical network might explain the perceptual and behavioral phenomena that are reported during focal electrical stimulation of the human brain.
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