A comparison of the discriminative stimulus effects of delta(9)-tetrahydrocannabinol and O-1812, a potent and metabolically stable anandamide analog, in rats.
Jenny L Wiley, Kari L LaVecchia, Natalie E Karp, Sanjitha Kulasegram, Anu Mahadevan, Raj K Razdan, Billy R Martin
Experimental and Clinical Psychopharmacology August 2004 DOI: 10.1037/1064-1297.12.3.173 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Animal discrimination study Peer reviewed |
|---|---|
| Population | Rats trained to discriminate Delta(9)-THC or O-1812 from vehicle |
| Interventions | Delta(9)-tetrahydrocannabinol (Delta(9)-THC) O-1812 SR141716A O-1839 |
| Topics | Cannabis |
| Key points | O-1812 and Delta(9)-THC substituted for each other in drug discrimination, but both were more potent in O-1812-trained rats, and O-1812 substituted for Delta(9)-THC only at response-rate-decreasing doses. SR141716A blocked the discriminative stimulus effects of both drugs while augmenting their rate effects, and the VR(1) agonist O-1839 did not substitute for either. The authors suggest the discriminative stimulus effects of Delta(9)-THC and O-1812 are similar but subtly different. |
Abstract
Efforts to determine whether Delta(9)-tetrahydrocannabinol (Delta(9)-THC) and anandamide elicit similar discriminative stimulus effects have yielded conflicting results. The difficulty in establishing a discriminative cue to anandamide may be due to its metabolic instability. Rats were trained to discriminate either Delta(9)-THC or O-1812, a metabolically stable anandamide analog, from vehicle to avoid this issue. O-1812 and Delta(9)-THC substituted for each other; however, both drugs were more potent in the O-1812-trained rats. Further, O-1812 only substituted for Delta(9)-THC at response rate decreasing doses. The CB(1) antagonist, SR141716A, blocked the discriminative stimulus effects of both drugs but augmented their rate effects. O-1839, a VR(1) agonist, failed to substitute for either cannabinoid. These results suggest that the discriminative stimulus effects of Delta(9)-THC and O-1812 are similar, but subtle differences also exist.
Comparable studies
Other preclinical and animal studies on cannabis, most cited first.
Citations in the library
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- Phenotypic assessment of THC discriminative stimulus properties in fatty acid amide hydrolase knockout and wildtype mice. Neuropharmacology June 2015
- Endocannabinoid contribution to Δ9-tetrahydrocannabinol discrimination in rodents. European Journal of Pharmacology August 15, 2014
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Cites 8
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- Delta9-THC training dose as a determinant for (R)-methanandamide generalization in rats. Psychopharmacology December 1998
- Evaluation of cannabimimetic effects of structural analogs of anandamide in rats. European Journal of Pharmacology August 21, 1998
- (R)-methanandamide, but not anandamide, substitutes for delta 9-THC in a drug-discrimination procedure. Experimental and Clinical Psychopharmacology August 1997
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