Auditory mismatch negativity deficits in long-term heavy cannabis users.
Patrik Roser, Beate Della, Christine Norra, Idun Uhl, Martin Brüne, Georg Juckel
European Archives of Psychiatry and Clinical Neuroscience September 2010 DOI: 10.1007/s00406-010-0097-y (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Observational cross-sectional study Randomized Peer reviewed |
|---|---|
| Sample size | 60 |
| Population | Age- and gender-matched chronic cannabis users and nonuser controls |
| Measures | Mismatch negativity (MMN) |
| Topics | Cannabis |
| Key findings | MMN values did not differ significantly between chronic cannabis users and nonusers overall, but long-term (8 or more years) and heavy (15 or more joints per week) users showed reduced frequency MMN amplitude at frontal electrodes compared with short-term and light users. The authors suggest that duration and quantity of cannabis use may be important factors in deficient MMN generation and that chronic use may cause a specific impairment of auditory information processing. |
Abstract
Mismatch negativity (MMN) is an auditory event-related potential indicating auditory sensory memory and information processing. The present study tested the hypothesis that chronic cannabis use is associated with deficient MMN generation. MMN was investigated in age- and gender-matched chronic cannabis users (n = 30) and nonuser controls (n = 30). The cannabis users were divided into two groups according to duration and quantity of cannabis consumption. The MMNs resulting from a pseudorandomized sequence of 2 × 900 auditory stimuli were recorded by 32-channel EEG. The standard stimuli were 1,000 Hz, 80 dB SPL and 90 ms duration. The deviant stimuli differed in duration (50 ms) or frequency (1,200 Hz). There were no significant differences in MMN values between cannabis users and nonuser controls in both deviance conditions. With regard to subgroups, reduced amplitudes of frequency MMN at frontal electrodes were found in long-term (≥8 years of use) and heavy (≥15 joints/week) users compared to short-term and light users. The results indicate that chronic cannabis use may cause a specific impairment of auditory information processing. In particular, duration and quantity of cannabis use could be identified as important factors of deficient MMN generation.
Comparable studies
Other cross-sectional and survey studies on cannabis, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Cannabis use before age 15 and subsequent executive functioning 104 chronic cannabis users (49 early-onset before age 15, 55 late-onset after age 15)... | 2011 | Observational cross-sectional study | n = 148 |
| Patterns of simultaneous polysubstance use in drug using university students Drug-using university students | 2006 | Cross-sectional survey | n = 149 |
| Persisting Reductions in Cannabis, Opioid, and Stimulant Misuse After Naturalistic Psychedelic Use: An Online Survey Online survey respondents | 2020 | Cross-sectional survey | |
| User perceptions of the benefits and harms of hallucinogenic drug use: A web-based questionnaire study Users of hallucinogenic drugs who completed a web-based questionnaire | 2010 | Cross-sectional survey | n = 600 |
| Illicit Use of LSD or Psilocybin, but not MDMA or Nonpsychedelic Drugs, is Associated with Mystical Experiences in a Dose-Dependent Manner Adults recruited from the MAPS website and newsletter, most reporting use of various... | 2012 | Cross-sectional survey | n = 337 |
Citations in the library
Cited by 4
- Gone to Pot – A Review of the Association between Cannabis and Psychosis Frontiers in Psychiatry May 22, 2014
- Mismatch Negativity and P50 Sensory Gating in Abstinent Former Cannabis Users Journal of Neural Transplantation and Plasticity February 25, 2016
- Alterations of theory of mind network activation in chronic cannabis users. Schizophrenia Research August 2012
- Neurophysiological and cognitive effects of smoked marijuana in frequent users. Pharmacology, Biochemistry, and Behavior September 2010
Cites 9
- Ketamine-Induced Deficits in Auditory and Visual Context-Dependent Processing in Healthy Volunteers Archives of General Psychiatry December 1, 2000
- Cannabidiol, a Cannabis sativa constituent, as an antipsychotic drug Brazilian Journal of Medical and Biological Research April 1, 2006
- Mismatch negativity generation in the human 5HT2A agonist and NMDA antagonist model of psychosis Psychopharmacology May 16, 2008
- Potential antipsychotic properties of central cannabinoid (CB1) receptor antagonists The World Journal of Biological Psychiatry March 1, 2010
- Cannabis and psychosis/schizophrenia: human studies European Archives of Psychiatry and Clinical Neuroscience July 16, 2009
and 4 more in the library