The effect of target-controlled infusion of low-dose ketamine on heat pain and temporal summation threshold.
Joon-Ho Lee, Sung-Hwan Cho, Sang-Hyun Kim, Won-Soek Chae, Hee-Cheol Jin, Jeong-Seok Lee, Yong-Ik Kim
Journal of Anesthesia August 2011 DOI: 10.1007/s00540-011-1147-y (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Sample size | 20 |
| Population | Healthy young volunteers |
| Intervention | Ketamine |
| Dose | effect-site concentration of 30 and 60 ng/ml |
| Measures | heat pain threshold (HPT), temporal summation threshold (TST), visual analog scale |
| Topics | Esketamine Ketamine |
| Key findings | Ketamine target-controlled infusion at effect-site concentrations of 30 and 60 ng/ml significantly increased temporal summation threshold in a dose-dependent fashion but did not significantly increase heat pain threshold. Vital signs remained unchanged, while psychedelic symptom visual analog scale scores were higher at 60 ng/ml than at 30 ng/ml. |
Abstract
We investigated the heat pain threshold (HPT) and temporal summation threshold (TST) before and after target-controlled infusion (TCI) of ketamine with an effect-site concentration (Ce) of 30 and 60 ng/ml. Healthy young volunteers (n = 20) were enrolled. A thermode was applied to the volar side of each volunteer's right forearm, and HPT and TST were measured before and after TCI of ketamine. Vital signs and psychedelic effects according to ketamine infusion were also observed before and after TCI of ketamine. Mean HPT after TCI of ketamine with a Ce of 30 and 60 ng/ml did not increase significantly. However, mean TST after TCI of ketamine with a Ce of 30 and 60 ng/ml increased significantly, in a dose-dependent fashion, compared with the value before ketamine TCI. Vital signs showed no significant difference before and after ketamine TCI. The visual analog scale score of psychedelic symptoms was higher with a Ce of 60 ng/ml than with 30 ng/ml. TCI of ketamine with a Ce of 30 and 60 ng/ml increased TST but not HPT.
Comparable studies
Other experimental studies on ketamine, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Ketamine activates psychosis and alters limbic blood flow in schizophrenia Schizophrenic individuals | 1995 | Experimental study | |
| The spectral exponent of the resting EEG indexes the presence of consciousness during unresponsiveness induced by propofol, xenon, and ketamine Healthy participants | 2019 | Controlled experimental study | n = 15 |
| Ketamine Increases Human Motor Cortex Excitability to Transcranial Magnetic Stimulation Normal human subjects | 2003 | Experimental study | n = 7 |
| Evidence that Subanesthetic Doses of Ketamine Cause Sustained Disruptions of NMDA and AMPA-Mediated Frontoparietal Connectivity in Humans Human participants | 2015 | Experimental study | |
| Simultaneous population pharmacokinetic modelling of ketamine and three major metabolites in patients with treatment‐resistant bipolar depression Patients with treatment-resistant bipolar depression | 2012 | Population pharmacokinetic analysis | n = 9 |
Citations in the library
Cites 5
- Ketamine Anesthesia & Analgesia November 1, 1998
- Use and efficacy of low-dose ketamine in the management of acute postoperative pain: a review of current techniques and outcomes Pain August 1, 1999
- Ketamine reduces muscle pain, temporal summation, and referred pain in fibromyalgia patients Pain April 1, 2000
- Psychedelic Effects of Ketamine in Healthy Volunteers Anesthesiology 1998
- Interaction of the chiral forms of ketamine with opioid, phencyclidine, sigma and muscarinic receptors. Pharmacology & Toxicology December 1, 1995