Oxidative stress in rat retina and hippocampus after chronic MDMA ('ecstasy') administration.
María Miranda, Francisco Bosch-Morell, Siv Johnsen-Soriano, Jorge Barcia, Inmaculada Almansa, Samuel Asensio, Javier Araiz, Angel Messeguer, Francisco J Romero
Neurochemical Research July 2007 DOI: 10.1007/s11064-007-9285-1 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Controlled animal experimental study Peer reviewed |
|---|---|
| Population | Rats |
| Interventions | MDMA CR-6 |
| Duration | 1 week of ecstasy administration |
| Measures | malondialdehyde (MDA), glutathione peroxidase (GPx), glutathione (GSH), TUNEL |
| Topics | MDMA |
| Key findings | One week of MDMA administration increased oxidative stress markers and reduced antioxidant defenses in rat liver, hippocampus, and retina, and increased TUNEL-positive nuclei in retinas, indicating apoptosis. The antioxidant CR-6 normalized these changes in all three tissues. |
Abstract
The effects of MDMA administration on oxidative stress markers in rat eye and hippocampus, and the neuroprotective effects of the antioxidant 3,4-dihydro-6-hydroxy-7-methoxy-2,2-dimethyl-1(2H)-benzopyran (CR-6) have been studied. MDMA effects on liver were used for comparison with those in eye and hippocampus and to test CR-6 protective effects. Another goal was to test for apoptosis in retinal cells, as it is known that happens in liver and brain. After 1 week of ecstasy administration, malondialdehyde (MDA) concentration increased, glutathione peroxidase (GPx) activity and glutathione (GSH) content decreased in liver, as previously described. MDA concentration increased and GPx activity decreased in hippocampus; whereas no change was observed in GSH concentration. MDMA decreased ocular GSH concentration and GPx activity; no change was observed in MDA concentration. The number of TUNEL-positive nuclei increased significantly in rat retinas after 1 week of MDMA administration. CR-6 normalized the modifications in liver, hippocampus and retina mentioned above.
Comparable studies
Other preclinical and animal studies on MDMA, most cited first.
Citations in the library
Cited by 4
- Effects of 3,4-methylenedioxymethamphetamine administration on retinal physiology in the rat. PLoS One June 14, 2016
- 3,4-Methylenedioxymethamphetamine causes cytotoxicity on 661W cells through inducing macrophage polarization. Cutaneous and Ocular Toxicology June 2018
- Human Ecstasy use is associated with increased cortical excitability: an fMRI study. Neuropsychopharmacology May 2011
- Neuropeptide Y protects retinal neural cells against cell death induced by ecstasy. Neuroscience March 3, 2008
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