Oxidative stress in rat kidneys due to 3,4-methylenedioxymetamphetamine (ecstasy) toxicity.
Milica Ninković, Vesna Selaković, Mirjana Dukić, Petar Milosavljević, Ivana Vasiljević, Marina Jovanović, Zivorad Malicevic
Nephrology February 2008 DOI: 10.1111/j.1440-1797.2007.00886.x (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Controlled experimental animal study Peer reviewed |
|---|---|
| Population | Adult male Wistar rats |
| Interventions | MDMA (3 4-methylenedioxymethamphetamine) |
| Dose | single oral dose: 5, 10, 20 or 40 mg/kg body weight; subacute: 5, 10, or 20 mg/kg body weight per day for 14 days |
| Duration | Acute group sacrificed 8 h after single dose; subacute group received MDMA daily for 14 days and was sacrificed after the last dose |
| Measures | rectal temperature, superoxide dismutase activity, thiobarbituric acid reactive substances, histological examination of the kidney |
| Topics | MDMA |
| Key findings | MDMA administration increased rectal temperature, superoxide dismutase activity, and thiobarbituric acid reactive substances in rats. Repeated daily MDMA for 14 days produced dose-dependent disruption of kidney tissue structure, which was not seen after a single dose. |
Abstract
The mechanism of MDMA (3,4-methylenedioxymethamphetamine)-induced toxicity is believed to be, in part, due to enhanced oxidative stress. As MDMA is eliminated via the kidney, the aim of this study was to investigate whether MDMA created conditions of oxidative stress within rat kidney. Adult male Wistar rats were divided into three groups, control treatment (water), acute MDMA administration (single oral dose: 5, 10, 20 or 40 mg/kg body weight) and subacute MDMA administration (5, 10, or 20 mg/kg body weight per day during 14 days). Animals were sacrificed 8 h after the single oral MDMA administration in the acute MDMA administration group and after the last MDMA administration in the subacute MDMA administration group. Rectal temperature measurements, oxidative stress status parameters and histological examinations were performed. In all MDMA-administered rats, rectal temperature markedly increased peaking approximately 1 h after MDMA ingestion. Superoxide dismutase activity and thiobarbituric acid reactive substances increased after MDMA administration. Histological examinations of the kidney revealed dose-dependent disruption of tissue structure in subacute MDMA-administered rats. The latter was not observed in acute MDMA-administered rats.
Comparable studies
Other preclinical and animal studies on MDMA, most cited first.
Citations in the library
Cited by 3
- Pro‐oxidant effects of Ecstasy and its metabolites in mouse brain synaptosomes British Journal of Pharmacology April 21, 2011
- Chiral separation of 3,4-methylenedioxymethamphetamine (MDMA) enantiomers using batch chromatography with peak shaving recycling and its effects on oxidative stress status in rat liver. Journal of Pharmaceutical and Biomedical Analysis January 25, 2013
- The agony of ecstasy: MDMA (3,4-methylenedioxymethamphetamine) and the kidney. Clinical journal of the American Society of Nephrology : CJASN November 2008
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and 3 more in the library