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Ergot and its alkaloids.

Paul L Schiff

American Journal of Pharmaceutical Education October 15, 2006 DOI: 10.5688/aj700598 (opens in new tab)

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Characteristics Review Peer reviewed
Key findings The manuscript reviews the history, pharmacognosy, isolation and preparation, chemistry, pharmacodynamics, and pharmacotherapeutics of ergot alkaloids and their derivatives, and briefly discusses the hallucinogenic properties of lysergic acid diethylamide. An abbreviated version of this material is presented in a four-hour didactic session to third-professional-year PharmD students within a Neurology/Psychiatry module.

Abstract

This manuscript reviews the history and pharmacognosy of ergot, and describes the isolation/preparation, chemistry, pharmacodynamics, and pharmacotherapeutics of the major ergot alkaloids and their derivatives. A brief discussion of the hallucinogenic properties of lysergic acid diethylamide is also featured. An abbreviated form of the material found in this paper is presented in a 4-hour didactic format to third-professional year PharmD students as part of their study of vascular migraine headaches, Parkinson's disease, and naturally occurring hallucinogens/hallucinogen derivatives in the modular course offering Neurology/Psychiatry.

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