Default Mode Network (DMN) Deactivation during Odor-Visual Association
P. Karunanayaka, Donald A. Wilson, Michael J. Tobia, Brittany Martinez, Mark D. Meadowcroft, P. Eslinger, Qing X. Yang
Human Brain Mapping October 27, 2016 DOI: 10.1002/hbm.23440 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Observational fMRI study Peer reviewed |
|---|---|
| Sample size | 29 |
| Population | Healthy, non-smoking, right-handed adults (mean age 26 ± 4 years, 16 females); 18 of the 29 also completed the control paradigm |
| Topics | Default mode network |
| Key findings | DMN deactivation was evoked by both odor-plus-visual and visual-only trials in the odor-visual association paradigm, but not by visual-only trials in the no-odor control paradigm. Directed connectivity between the DMN and olfactory network differed significantly between the two trial conditions. The authors argue this supports a strong interaction between the DMN and olfactory network and a role for the DMN in task-evoked brain activity and behavioral responses during olfactory processing. |
Abstract
Default mode network (DMN) deactivation has been shown to be functionally relevant for goal‐directed cognition. In this study, the DMN's role during olfactory processing was investigated using two complementary functional magnetic resonance imaging (fMRI) paradigms with identical timing, visual‐cue stimulation, and response monitoring protocols. Twenty‐nine healthy, non‐smoking, right‐handed adults (mean age = 26 ± 4 years, 16 females) completed an odor–visual association fMRI paradigm that had two alternating odor + visual and visual‐only trial conditions. During odor + visual trials, a visual cue was presented simultaneously with an odor, while during visual‐only trial conditions the same visual cue was presented alone. Eighteen of the twenty‐nine participants (mean age = 27.0 ± 6.0 years, 11 females) also took part in a control no‐odor fMRI paradigm that consisted of a visual‐only trial condition which was identical to the visual‐only trials in the odor–visual association paradigm. Independent Component Analysis (ICA), extended unified structural equation modeling (euSEM), and psychophysiological interaction (PPI) were used to investigate the interplay between the DMN and olfactory network. In the odor–visual association paradigm, DMN deactivation was evoked by both the odor + visual and visual‐only trial conditions. In contrast, the visual‐only trials in the no‐odor paradigm did not evoke consistent DMN deactivation. In the odor–visual association paradigm, the euSEM and PPI analyses identified a directed connectivity between the DMN and olfactory network which was significantly different between odor + visual and visual‐only trial conditions. The results support a strong interaction between the DMN and olfactory network and highlights the DMN's role in task‐evoked brain activity and behavioral responses during olfactory processing. Hum Brain Mapp 38:1125–1139, 2017. © 2016 Wiley Periodicals, Inc.
Comparable studies
Other experimental studies on default mode network, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Functional connectivity of default mode network components: Correlation, anticorrelation, and causality Healthy subjects | 2008 | Observational study using resting-state fMRI and seed correlation analysis | |
| Patterns of Brain Activity Supporting Autobiographical Memory, Prospection, and Theory of Mind, and Their Relationship to the Default Mode Network Healthy subjects | 2009 | Experimental study using fMRI | |
| Dynamic reconfiguration of the default mode network during narrative comprehension Human subjects | 2016 | Experimental study | |
| Broadband Cortical Desynchronization Underlies the Human Psychedelic State Healthy human participants | 2013 | Experimental study | |
| The brain on art: intense aesthetic experience activates the default mode network Human observers | 2012 | Observational study with fMRI and behavioral analysis |
Citations in the library
Cites 3
- A default mode of brain function Proceedings of the National Academy of Sciences January 16, 2001
- Resting-State Functional Connectivity Reflects Structural Connectivity in the Default Mode Network Cerebral Cortex April 9, 2008
- Functional connectivity in the resting brain: A network analysis of the default mode hypothesis Proceedings of the National Academy of Sciences December 27, 2002