Disrupted Resting-State Default Mode Network in Betel Quid-Dependent Individuals
Xue-Ling Zhu, Qiuling Zhu, Can-Hua Jiang, Huaizhen Shen, Furong Wang, W. Liao, Fu-Lai Yuan
Frontiers in Psychology January 30, 2017 DOI: 10.3389/fpsyg.2017.00084 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Case-control study Peer reviewed |
|---|---|
| Sample size | 54 |
| Population | 26 individuals with betel quid dependence and 28 matched healthy control subjects |
| Measures | Betel Quid Dependence Scale (BQDS) |
| Topics | Default mode network |
| Key findings | Betel quid-dependent individuals showed decreased resting-state functional connectivity in the anterior default mode network, including the ventral medial prefrontal cortex and orbitomedial prefrontal/anterior cingulate cortex, compared with healthy controls. Connectivity within the orbitomedial prefrontal/anterior cingulate cortex was negatively correlated with Betel Quid Dependence Scale scores (r = -0.49), indicating greater dependence severity was associated with lower connectivity. The authors propose this as new evidence for the default mode network's role in betel quid dependence pathophysiology. |
Abstract
Recent studies have shown that substance dependence (addiction) is accompanied with altered activity patterns of the default mode network (DMN). However, the neural correlates of the resting-state DMN and betel quid dependence (BQD)-related physiopathological characteristics still remain unclear. Resting-state functional magnetic resonance imaging images were obtained from 26 BQD individuals and 28 matched healthy control subjects. Group independent component analysis was performed to analyze the resting state images into spatially independent components. Gray matter volume was examined as covariate with voxel-based morphometry to rule out its effect on the functional results. The severity of BQD was assessed by the BQD Scale (BQDS). We observed decreased functional connectivity in anterior part of the DMN including ventral medial prefrontal cortex, orbital MPFC (OMPFC)/anterior cingulate cortex (ACC). Furthermore, the functional connectivity within the OMPFC/ACC in BQD individuals was negatively correlated with BQDS (p = 0.01, r = -0.49). We reported decreased functional connectivity within anterior part of the DMN in BQD individuals, which provides new evidence for the role of the DMN in the pathophysiology of BQD.
Comparable studies
Other observational and cohort studies on default mode network, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| A default mode of brain function Normal adult human brain | 2001 | Observational study | |
| Resting-State Functional Connectivity Reflects Structural Connectivity in the Default Mode Network Healthy subjects | 2008 | Observational cohort | |
| Meditation experience is associated with increased cortical thickness Participants with extensive Insight meditation experience and matched controls | 2005 | Observational cohort | n = 20 |
| Meditation experience is associated with differences in default mode network activity and connectivity Experienced meditators and matched meditation-naive controls | 2011 | Observational cohort | |
| The precuneus/posterior cingulate cortex plays a pivotal role in the default mode network: Evidence from a partial correlation network analysis Healthy subjects | 2008 | Observational study |
Citations in the library
Cites 3
- A default mode of brain function Proceedings of the National Academy of Sciences January 16, 2001
- Investigating the Functional Heterogeneity of the Default Mode Network Using Coordinate-Based Meta-Analytic Modeling Journal of Neuroscience November 18, 2009
- Functional connectivity in the resting brain: A network analysis of the default mode hypothesis Proceedings of the National Academy of Sciences December 27, 2002