Task-Evoked Negative BOLD Response in the Default Mode Network Does Not Alter Its Functional Connectivity.
Qolamreza R Razlighi
Frontiers in Computational Neuroscience 2018 DOI: 10.3389/fncom.2018.00067 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Functional neuroimaging study (fMRI) Peer reviewed |
|---|---|
| Intervention | Simple visual-motor task |
| Topics | Default mode network |
| Keywords | Brain large-scale networks FMRI Bold Functional connectivity Functional Neuroimaging FMRI Negative bold response Task-evoked activity Visual network |
| Key points | Performing a simple visual-motor task altered the temporal time-course of the functional connectivity network extracted from the primary visual cortex, but did not alter the functional connectivity of default mode network regions, even though a robust task-evoked negative BOLD response was detected there. The authors suggest that different mechanisms may underlie the relationship between task-related activation or deactivation and overlapping functional connectivity networks. |
Abstract
While functional connectivity networks are often extracted from resting-state fMRI scans, they have been shown to be active during task performance as well. However, the effect of an in-scanner task on functional connectivity networks is not completely understood. While there is evidence that task-evoked positive BOLD response can alter functional connectivity networks, particularly in the primary sensorimotor cortices, the effect of task-evoked negative BOLD response on the functional connectivity of the Default mode network (DMN) is somewhat ambiguous. In this study, we aim to investigate whether task performance, which is associated with negative BOLD response in the DMN regions, alters the time-course of functional connectivity in the same regions obtained by independent component analysis (ICA). ICA has been used to effectively extract functional connectivity networks during task performance and resting-state. We first demonstrate that performing a simple visual-motor task alters the temporal time-course of the network extracted from the primary visual cortex. Then we show that despite detecting a robust task-evoked negative BOLD response in the DMN regions, a simple visual-motor task does not alter the functional connectivity of the DMN regions. Our findings suggest that different mechanisms may underlie the relationship between task-related activation/deactivation networks and the overlapping functional connectivity networks in the human large-scale brain networks.
Comparable studies
Other experimental studies on default mode network, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Functional connectivity of default mode network components: Correlation, anticorrelation, and causality Healthy subjects | 2008 | Observational study using resting-state fMRI and seed correlation analysis | |
| Patterns of Brain Activity Supporting Autobiographical Memory, Prospection, and Theory of Mind, and Their Relationship to the Default Mode Network Healthy subjects | 2009 | Experimental study using fMRI | |
| Dynamic reconfiguration of the default mode network during narrative comprehension Human subjects | 2016 | Experimental study | |
| Broadband Cortical Desynchronization Underlies the Human Psychedelic State Healthy human participants | 2013 | Experimental study | |
| The brain on art: intense aesthetic experience activates the default mode network Human observers | 2012 | Observational study with fMRI and behavioral analysis |
Citations in the library
Cites 3
- A default mode of brain function Proceedings of the National Academy of Sciences January 16, 2001
- Default mode network connectivity: effects of age, sex, and analytic approach Neuroreport May 28, 2008
- Functional connectivity in the resting brain: A network analysis of the default mode hypothesis Proceedings of the National Academy of Sciences December 27, 2002