Influence of propofol on the electroencephalogram default mode network in patients of advanced age
Jing-Dong Ke, Min Xu, Peipei Wang, Min Wang, Ming Guo Tian, Andrew C.N. Chen
Journal of International Medical Research September 23, 2018 DOI: 10.1177/0300060518788241 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Observational study Peer reviewed |
|---|---|
| Sample size | 15 |
| Population | Men aged over 60 years (mean 70 years) |
| Intervention | Propofol |
| Measures | EEG bispectral index, EEG spectral power in seven bands (delta, theta, alpha-1, alpha-2, beta-1, beta-2, gamma), brain topographic map, propofol target effect-site concentration, blood pressure, heart rate |
| Topics | Default mode network |
| Citations | 2 |
| Key findings | In 15 men of advanced age, propofol anesthesia shifted EEG energy toward frontoparietal regions for delta, theta, alpha-1, alpha-2, and beta-1 bands, with significantly increased power, while beta-2 and temporal gamma energy and power decreased. The authors present these as changes in the spatial distribution and regional energy of the default mode network between wakefulness and anesthesia. |
Abstract
Objective: This study was performed to evaluate the effects of propofol on the electroencephalogram (EEG) default mode network (DMN) in patients of advanced age.
Methods: Fifteen men aged >60 years (mean, 70 years) were selected. Propofol target-controlled infusion was performed under EEG bispectral index monitoring. The propofol target effect-site concentration, blood pressure, heart rate, and distributions and powers of the EEG spectrum were recorded in an awake state and under anesthesia. The EEG included seven bands: delta (0.5-3.5 Hz), theta (4.0-7.0 Hz), alpha-1 (7.5-9.5 Hz), alpha-2 (10-12 Hz), beta-1 (13-23 Hz), beta-2 (24-34 Hz), and gamma (35-45 Hz).
Results: From an awake state to anesthesia, the brain topographic map showed that the energies of delta, theta, alpha-1, alpha-2, and beta-1 were concentrated in the frontoparietal site, and the power increased significantly. The energy distribution of beta-2 was significantly decreased and the power significantly reduced. The energy distribution of gamma in the temporal lobe was also markedly decreased and the power significantly reduced.
Conclusions: This study revealed the changes in the spatial distribution and regional energy of the EEG DMD in men of advanced age from the awake state to the anesthetized state.
Comparable studies
Other observational and cohort studies on default mode network, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| A default mode of brain function Normal adult human brain | 2001 | Observational study | |
| Resting-State Functional Connectivity Reflects Structural Connectivity in the Default Mode Network Healthy subjects | 2008 | Observational cohort | |
| Meditation experience is associated with increased cortical thickness Participants with extensive Insight meditation experience and matched controls | 2005 | Observational cohort | n = 20 |
| Meditation experience is associated with differences in default mode network activity and connectivity Experienced meditators and matched meditation-naive controls | 2011 | Observational cohort | |
| The precuneus/posterior cingulate cortex plays a pivotal role in the default mode network: Evidence from a partial correlation network analysis Healthy subjects | 2008 | Observational study |