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Web-based Mindfulness-based Cognitive Therapy for reducing residual depressive symptoms: An open trial and quasi-experimental comparison to propensity score matched controls.

Sona Dimidjian, Arne Beck, Jennifer N. Felder, Jennifer M. Boggs, Robert Gallop, Zindel V. Segal

Behaviour Research and Therapy December 2014 DOI: 10.1016/j.brat.2014.09.004 (opens in new tab)

Study at a glance

AI-extracted from the abstract
Characteristics Open trial with quasi-experimental propensity-matched comparison Peer reviewed
Sample size 100
Population Recurrently depressed adults, including a subgroup with residual depressive symptoms (N = 42); 107 individuals were screened
Intervention Mindful Mood Balance (MMB)
Duration 8-session intervention with 6-month follow-up
Topics Depression Meditation
Keywords Dissemination Mindfulness-based cognitive therapy Residual depressive symptoms Web-based treatments
Key findings MMB was associated with significantly reduced depressive symptom severity sustained over six months and improved rumination and mindful awareness in the full sample and the RDS subgroup, and with greater reduction in RDS severity than propensity-matched usual depression care controls. The authors conclude the findings support web-based delivery of MBCT and suggest clinical benefits for people with histories of depression and RDS, while noting the non-randomized design and short follow-up as limitations.

Abstract

Mindfulness-based Cognitive Therapy (MBCT) has been shown to effectively prevent relapse and reduce residual depressive symptoms (RDS), yet it faces barriers to dissemination. The present study examined Mindful Mood Balance (MMB), the first web-based approach to deliver the core content of MBCT. Of the 107 recurrently depressed individuals screened, 100 elected to enroll in the study and received MMB in an 8-session open trial with 6-month follow-up. Outcomes included depressive symptom severity, rumination and mindful awareness, and program engagement. A quasi-experimental comparison between MMB participants and propensity matched case-controls receiving usual depression care (UDC) (N = 100) also was conducted. The full sample and the subgroup with residual depressive symptoms (N = 42) showed significantly reduced depressive severity, which was sustained over six months, and improvement on rumination and mindfulness. Examination of acceptability of MMB indicated that 42% of participants within the full sample and 36% of the RDS subgroup completed all 8 sessions and 53% within the full sample and 50% within the RDS subgroup completed at least 4 sessions, and that participants engaged with daily mindfulness practice. MMB also was associated with significant reduction in RDS severity as compared to quasi-experimental propensity matched controls. Although the use of a non-randomized design, with potential unmeasured differences between groups, and short interval of clinical follow-up were limitations, findings from this study support the web-based delivery of MBCT and suggest clinical benefits for participants with histories of depression and with RDS, relative to those receiving usual care alone.

Comparable studies

Other non-randomized and open-label trials on meditation, most cited first.

Study Year Design Participants
Mindfulness-Based Stress Reduction in Relation to Quality of Life, Mood, Symptoms of Stress, and Immune Parameters in Breast and Prostate Cancer Outpatients Early-stage breast and prostate cancer patients 2003 Pre-post intervention study n = 59
Exploring self‐compassion and empathy in the context of mindfulness‐based stress reduction (MBSR) Community sample 2010 Pre-post intervention study
Mindfulness-Based Stress Reduction Lowers Psychological Distress In Medical Students Second-year medical students 2003 Prospective nonrandomized cohort-controlled study n = 302
Intensive meditation training, immune cell telomerase activity, and psychological mediators. Retreat participants and matched controls 2011 Controlled trial with wait-list control group n = 60
The Effectiveness of Mindfulness Training for Children with ADHD and Mindful Parenting for their Parents Children aged 8-12 with ADHD and their parents 2011 Within-group waitlist controlled trial n = 22

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