The effectiveness of adjunct mindfulness-based intervention in treatment of bipolar disorder: A systematic review and meta-analysis.
Che‐sheng Chu, Brendon Stubbs, Tien-Yu Chen, Chia-Hung Tang, Dian‐jeng Li, Wei-Cheng Yang, Ching-Kuan Wu, André F. Carvalho, Eduard Vieta, David J. Miklowitz, Ping-Tao Tseng, Pao-Yen Lin
Journal of Affective Disorders January 1, 2018 DOI: 10.1016/j.jad.2017.08.025 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Systematic review and meta-analysis Peer reviewed |
|---|---|
| Sample size | 274 |
| Population | People with bipolar disorder |
| Intervention | Mindfulness-based interventions |
| Topics | Meditation |
| Keywords | Adjunctive treatment Cognitive behavioral therapy |
| Key findings | Across 12 trials, mindfulness-based interventions were associated with reduced depressive and anxiety symptoms when compared with baseline, but not with manic symptoms or cognition. In the three controlled comparisons against waiting-list groups, no significant reductions in depressive or anxiety symptoms were observed. The authors conclude that further trials are needed to clarify differences between treatment and control groups. |
Abstract
Mindfulness-based interventions (MBIs) have been increasingly used as an adjunctive treatment to pharmacotherapy for a few psychiatric disorders. However, few studies have investigated the efficacy of MBIs in bipolar disorder (BD). We performed a systematic review and meta-analysis to evaluate the efficacy of MBIs as an adjunctive treatment in BD. Major electronic databases were independently searched by two authors for controlled and uncontrolled studies which examined the effects of MBIs on psychiatric symptoms in subjects with BD. Data from original studies were synthesized by using a random effects model. Twelve trials were eligible for inclusion into current meta-analysis, including three controlled studies (n=132) and nine uncontrolled studies (n=142). In within-group analysis, MBIs significantly reduced depressive (7 studies, n=100, Hedges' g=0.58, p<0.001) and anxiety (4 studies, n=68, Hedges' g=0.34, p=0.043) symptoms, but not manic symptoms (6 studies, n=89, Hedges' g=0.09, p=0.488) and cognition (3 studies, n=43, Hedges' g=0.35, p=0.171), compared to baseline. In between-group analysis (intervention group versus waiting list group, all patients with BD), MBIs did not reduce depressive (3 studies, n=132, Hedges' g=0.46, p=0.315) or anxiety (3 studies, n=132, Hedges' g=0.33, p=0.578) symptoms. Only three controlled trials compared MBIs to control conditions. Our meta-analysis showed significantly beneficial effects on depressive and anxiety symptoms of BD patients in within-group analysis. However, this significance was not observed in comparison with the control groups. Further clinical trials are warranted to investigate the differences in the benefits of MBIs between treatment and control subjects.
Comparable studies
Other systematic reviews and meta-analyses on meditation, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Meditation Programs for Psychological Stress and Well-being Diverse adult clinical populations | 2014 | Meta-analysis | n = 3,515 |
| Mindfulness-Based Stress Reduction for Stress Management in Healthy People: A Review and Meta-Analysis Healthy subjects | 2009 | Systematic review and meta-analysis | |
| The psychological effects of meditation: A meta-analysis. Nonclinical groups of adult meditators | 2012 | Meta-analysis | n = 163 |
| Efficacy of Mindfulness-Based Cognitive Therapy in Prevention of Depressive Relapse Adults with recurrent depression in full or partial remission | 2016 | Meta-analysis of individual patient data from randomized controlled trials | n = 1,258 |
| Mindfulness‐Based Stress Reduction and Mindfulness‐Based Cognitive Therapy – a systematic review of randomized controlled trials | 2011 | Systematic review |
Citations in the library
Cited by 21
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- Web-based intervention to improve quality of life in late stage bipolar disorder (ORBIT): randomised controlled trial protocol BMC Psychiatry July 12, 2018
- Examining the Use of Virtual Reality to Support Mindfulness Skills Practice in Mood and Anxiety Disorders: Mixed Methods Study. Journal of Medical Internet Research December 6, 2024
- A Systematic Review on the State of the Art of Culturally Adapted Mindfulness-Based Interventions for First Nations Peoples: Cultural Adaptation, Effectiveness, and Feasibility Mindfulness September 1, 2024
and 16 more in the library
Cites 18
- Prevention of relapse/recurrence in major depression by mindfulness-based cognitive therapy. Journal of Consulting and Clinical Psychology 2000
- Efficacy of Mindfulness-Based Cognitive Therapy in Prevention of Depressive Relapse JAMA Psychiatry April 28, 2016
- Standardised Mindfulness-Based Interventions in Healthcare: An Overview of Systematic Reviews and Meta-Analyses of RCTs PLoS One April 16, 2015
- Mindfulness-Based Cognitive Therapy: Theory and Practice The Canadian Journal of Psychiatry February 1, 2012
- Mindfulness-based cognitive therapy: Evaluating current evidence and informing future research. Journal of Consulting and Clinical Psychology 2007
and 13 more in the library