Dopaminergic and Serotonergic Genotypes and the Subjective Experiences of Hypnosis.
E R Katonai, Anna Szekely, A Vereczkei, Maria Sasvari-Szekely, Éva Bányai, Katalin Varga
International Journal of Clinical and Experimental Hypnosis October 1, 2017 DOI: 10.1080/00207144.2017.1348848 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Genetic association study Peer reviewed |
|---|---|
| Sample size | 136 |
| Population | Adults who participated in hypnosis and provided noninvasive DNA samples |
| Intervention | Hypnosis |
| Measures | Archaic Involvement Measure (AIM), Phenomenology of Consciousness Inventory (PCI), Dyadic Interactional Harmony Questionnaire (DIH) |
| Topics | Serotonin |
| Keywords | Humans Catechol o-methyltransferase Hypnosis Psychological tests Genotype Models, psychological Female Young adult Genetic association studies Surveys and questionnaires |
| Key points | The 'Need of dependence' subscale of the Archaic Involvement Measure was associated with COMT genotypes, with the GG subgroup scoring higher and the AA subgroup scoring below average on most subjective measures. The 5-HTTLPR polymorphism was also associated with intimacy scores on the Dyadic Interactional Harmony Questionnaire. The authors discuss these effects within the social-psychobiological model of hypnosis. |
Abstract
Hypnotizability is related to the Val158Met polymorphism of the COMT gene. The authors' aim was to find associations between candidate genes and subjective dimensions of hypnosis; 136 subjects participated in hypnosis and noninvasive DNA sampling. The phenomenological dimensions were tapped by the Archaic Involvement Measure (AIM), the Phenomenology of Consciousness Inventory (PCI), and the Dyadic Interactional Harmony Questionnaire (DIH). The main results were that the "Need of dependence" subscale of AIM was associated with the COMT genotypes. The GG subgroup showed higher scores, whereas AA had below average scores on the majority of the subjective measures. An association between the 5-HTTLPR polymorphism and the intimacy scores on the DIH was also evident. The effects are discussed in the social-psychobiological model of hypnosis.