Hyperconnectivity of the default mode network in multiorgan dysfunction syndrome
Antonio Jiménez-Marín, Diego F. Rivera, Victoria Boado, Ibai Palacio Diez, Fermín Labayen, Irati Garrido, Daniela Ramos‐Usuga, Javier Rasero, A Cabrera, Sebastiano Stramaglia, Juan Carlos Arango‐Lasprilla, Jesús M. Cortés
bioRxiv (Cold Spring Harbor Laboratory) September 14, 2018 preprint DOI: 10.1101/418160 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Case-control neuroimaging study |
|---|---|
| Sample size | 26 |
| Population | MODS patients with no apparent brain damage at 6 months after ICU discharge and healthy controls matched by age, sex, and years of education |
| Duration | 6 months after ICU discharge |
| Topics | Default mode network |
| Key findings | MODS patients with no apparent brain damage showed increased resting-state functional connectivity compared with healthy controls, including hyperconnectivity of the default mode network with primary sensory, multimodal integration, and higher-order cognition networks. The authors propose this may indicate a compensatory brain mechanism after MODS. |
Abstract
Abstract Multiple Organ Dysfunction Syndrome (MODS) is a systemic physiological disorder affecting two or more body organs triggered after an insult complication. Beyond the systemic failure, patients who survive MODS present cognitive and neurological impairments that remain stable even several years after Intensive Care Unit (ICU) discharge. Here, we focus on the specific situation of MODS patients with no apparent brain damage (NABD), where the mechanisms driving cognitive impairment at long term are not well-understood. We recruit N 1 = 13 MODS patients with NABD at 6 months after ICU discharge, together with N 2 = 13 healthy controls (matched by age, sex and years of education), and acquire functional magnetic resonance imaging at rest to find that, as compared to control, MODS patients with NABD present an overall increase of the functional connectivity (FC) at rest. In particular, we find that the default mode network (DMN) hyperconnects (increasing the node strength of the FC matrix) to three classes of networks: primary sensory (such as auditory, sensory-motor and visual), multimodal integration (such as dorsal attention and salience) and higher order cognition networks (such as fronto-parietal, language and executive control). Therefore, although these patients do not have an apparent structural damage after MODS, at the functional level, we found brain network alterations coexisting with hyperconnectivity of the DMN, that similar to what happens at the onset of other pathologies, might indicate a possible mechanism for brain compensation occurring after MODS.
Comparable studies
Other experimental studies on default mode network, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Functional connectivity of default mode network components: Correlation, anticorrelation, and causality Healthy subjects | 2008 | Observational study using resting-state fMRI and seed correlation analysis | |
| Patterns of Brain Activity Supporting Autobiographical Memory, Prospection, and Theory of Mind, and Their Relationship to the Default Mode Network Healthy subjects | 2009 | Experimental study using fMRI | |
| Dynamic reconfiguration of the default mode network during narrative comprehension Human subjects | 2016 | Experimental study | |
| Broadband Cortical Desynchronization Underlies the Human Psychedelic State Healthy human participants | 2013 | Experimental study | |
| The brain on art: intense aesthetic experience activates the default mode network Human observers | 2012 | Observational study with fMRI and behavioral analysis |
Citations in the library
Cites 3
- A default mode of brain function Proceedings of the National Academy of Sciences January 16, 2001
- Breakdown of within- and between-network Resting State Functional Magnetic Resonance Imaging Connectivity during Propofol-induced Loss of Consciousness Anesthesiology September 30, 2010
- Resting State Networks and Consciousness Frontiers in Psychology 2012