S17. ZNF804A GENE AND CANNABIS USE: INTERACTION ON THE RISK FOR PSYCHOSIS IN A NON-CLINICAL SAMPLE
Jordi Soler García, Bárbara Arias, Jorge Moya, M. Ibáñez, Generós Ortet, Lourdes Fañanás, Mar Fatjó‐Vilas
Schizophrenia Bulletin April 1, 2018 DOI: 10.1093/schbul/sby018.804 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Cross-sectional genetic association study Peer reviewed |
|---|---|
| Sample size | 389 |
| Population | Spanish non-clinical subjects, 43% male, mean age 21.1 years (SD 2.19) |
| Measures | Schizotypal Personality Questionnaire-Brief (SPQ-B): Cognitive-Perceptual (CP), Interpersonal (I), Disorganized (D); SCL anxiety scores |
| Topics | Cannabis |
| Key findings | The ZNF804A variant rs1344706 was linearly associated with Interpersonal schizotypy, with AA homozygotes scoring higher. Cannabis use interacted with genotype on Cognitive-Perceptual schizotypy: among AA individuals, cannabis users had higher scores than non-users, while among CC individuals, users had lower scores than non-users. The authors suggest schizotypy is influenced by an interaction between cannabis exposure and ZNF804A genotype. |
Abstract
Abstract Background The ZNF804A gene and cannabis use are risk factors for psychosis, both of which have also been associated with schizotypic traits. This study aimed to test whether ZNF804A (rs1344706) modulates the relation between cannabis use and schizotypy levels in a general population sample.
Methods: The sample consisted of 389 Spanish non-clinical subjects (43% males, mean age=21.1(2.19)). Schizotypy was evaluated with the three factors of the Schizotypal Personality Questionnaire-Brief (SPQ-B): Cognitive-Perceptual (CP), Interpersonal (I) and Disorganized (D). Subjects were classified as cannabis users or non-users. Multiple linear regressions were conducted to test the effect of genetic and environment factors and their interaction on SPQ-B scores. Sex and anxiety scores (evaluated with SCL) were included as covariates.
Results: The analyses showed a significant linear relationship between the ZNF804A and SPQ-I: homozygotes AA showed higher scores (p=0.001). An interaction between cannabis use and rs1344706 on SPQ-CP was observed: among individuals AA, cannabis users presented higher scores than non-users, while among individuals CC, cannabis users presented lower scores compared to non-users (p=0.005).
Discussion: These results add evidence on that the ZNF804A modulates schizotypy and suggest that schizotypy levels are influenced by an interaction between the exposure to cannabis and the ZNF804A genotype.
Comparable studies
Other cross-sectional and survey studies on cannabis, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Cannabis use before age 15 and subsequent executive functioning 104 chronic cannabis users (49 early-onset before age 15, 55 late-onset after age 15)... | 2011 | Observational cross-sectional study | n = 148 |
| Patterns of simultaneous polysubstance use in drug using university students Drug-using university students | 2006 | Cross-sectional survey | n = 149 |
| Persisting Reductions in Cannabis, Opioid, and Stimulant Misuse After Naturalistic Psychedelic Use: An Online Survey Online survey respondents | 2020 | Cross-sectional survey | |
| User perceptions of the benefits and harms of hallucinogenic drug use: A web-based questionnaire study Users of hallucinogenic drugs who completed a web-based questionnaire | 2010 | Cross-sectional survey | n = 600 |
| Illicit Use of LSD or Psilocybin, but not MDMA or Nonpsychedelic Drugs, is Associated with Mystical Experiences in a Dose-Dependent Manner Adults recruited from the MAPS website and newsletter, most reporting use of various... | 2012 | Cross-sectional survey | n = 337 |