Dynamic Connectivity Patterns in Conscious and Unconscious Brain.
Yuncong Ma, Christina Hamilton, Nanyin Zhang
Brain Connectivity February 2017 DOI: 10.1089/brain.2016.0464 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Observational study Peer reviewed |
|---|---|
| Population | Rats |
| Keywords | Anesthetic-induced unconsciousness Dynamic functional connectivity Rat Resting-state networks |
| Key findings | Whole-brain functional networks in rats contained several quasi-stable connectivity patterns that dynamically recurred from wakefulness into graded anesthetic states. Two connectivity states, differing in their spatial similarity to anatomical connectivity structure, were strongly biased toward high and low consciousness levels, respectively, which the authors present as evidence linking functional connectivity dynamics to consciousness at the behavioral level. |
Abstract
Brain functional connectivity undergoes dynamic changes from the awake to unconscious states. However, how the dynamics of functional connectivity patterns are linked to consciousness at the behavioral level remains elusive. In this study, we acquired resting-state functional magnetic resonance imaging data during wakefulness and graded levels of consciousness in rats. Data were analyzed using a dynamic approach combining the sliding window method and k-means clustering. Our results demonstrate that whole-brain networks contained several quasi-stable patterns that dynamically recurred from the awake state into anesthetized states. Remarkably, two brain connectivity states with distinct spatial similarity to the structure of anatomical connectivity were strongly biased toward high and low consciousness levels, respectively. These results provide compelling neuroimaging evidence linking the dynamics of whole-brain functional connectivity patterns and states of consciousness at the behavioral level.
Citations in the library
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- LSD alters dynamic integration and segregation in the human brain. Neuroimage February 15, 2021
- Dynamic functional connectivity and brain metastability during altered states of consciousness Neuroimage October 3, 2017
- Local orchestration of distributed functional patterns supporting loss and restoration of consciousness in the primate brain. Nature Communications March 11, 2024
- Dynamic reconfiguration of frequency-specific cortical coactivation patterns during psychedelic and anesthetized states induced by ketamine Neuroimage January 7, 2022
- Unravelling consciousness and brain function through the lens of time, space, and information Trends in Neurosciences May 31, 2024
and 8 more in the library
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