An Introduction to Cannabis
Cannabinoids and the Brain March 1, 2017 DOI: 10.7551/mitpress/9780262035798.003.0001 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Peer reviewed |
|---|---|
| Topics | Cannabis |
| Key points | Reports that THC was isolated in the 1960s and the CB1 receptor discovered about 20 years later; that cannabis contains over 80 cannabinoids but THC is the only intoxicating one; and that preclinical research is evaluating other cannabinoids such as CBD for therapeutic potential. Chapter 1 covers THC pharmacokinetics, administration methods, and dosing. |
Abstract
Although cannabis has been used throughout human history, the scientific investigation of its effects only began with the isolation of THC in the 1960’s. Once discovered it was another 20 years before the mechanism by which THC produces its psychoactive effects in the brain, the CB1 receptor, was discovered. Cannabis contains over 80 cannabinoid compounds, but THC is the only intoxicating compound. Recent preclinical research is being directed towards evaluating the therapeutic potential of other cannabinoid compounds found in cannabis, including CBD. The pharmacokinetics of THC, methods of administration, and dosing issues are explored in Chapter 1.