Bonsai intoxication at emergency service: A review of 61 cases
Nadiye Karabulut, Ayşe Seda Demirel Dengi, Sündüs Görükmez, Secil Gunher Arica, Selman Yeniocak
Journal of Surgery and Medicine July 10, 2018 DOI: 10.28982/josam.422416 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Retrospective observational study Peer reviewed |
|---|---|
| Sample size | 61 |
| Population | Patients diagnosed with bonsai (synthetic cannabinoid) intoxication monitored in an emergency service |
| Intervention | midazolam |
| Dose | 0.9% NaCl solution, 15cc/min, 2000 cc |
| Measures | Glasgow coma score (GCS), pupil reflex, serum creatine kinase (CK), creatine kinase myocardial band (CK-MB), troponin-I, electrocardiogram (ECG), hemogram, coagulation parameters, venous blood gas, venous blood glucose |
| Citations | 1 |
| Key findings | Among 61 bonsai intoxication cases, most presented with severely reduced consciousness (87% with Glasgow Coma Score 8; 90% with fixed dilated pupils), while biochemical and blood gas parameters were largely normal, though 21% showed elevated creatine kinase and CK-MB. Blood glucose inversely correlated with coma score. The authors argue that synthetic cannabinoid use should be considered in the pre-diagnosis of adolescents presenting to emergency services with loss of consciousness. |
Abstract
Aim: The aim of this study was to determine the effects of bonzai by assessing the correlation between the clinical and laboratory findings of cases diagnosed with bonsai intoxication who had been monitored in the emergency service.Methods: This study was approved by ‘’Haseki Training and Research Hospital Ethical Committee of Non-Pharmacological Studies’’ with approval number of:183 on 28.01.2015. A retrospective evaluation was performed on 61 bonsai intoxication cases who had been monitored and treated in the emergency service. The clinical findings of the pre- and post-treatment and laboratory findings of each case were evaluated.
Results: According to the initial clinical assessment of bonsai intoxication cases who were admitted to the emergency service, the Glasgow coma score (GCS) was found as 8 (E2, V2, M4), 9 (E2, V2, M5) and 4 (E1, V1, M2) in 87% (n=53), 10% (n=6) and 3.2% (n=2), respectively. The pupil reflex was fixed and dilated in 90% (n=52); whereas, it was normal in 10% (n=9). Although, the biochemical parameters (78.9%, n=49) and blood gas levels (98.6%, n=60) were within the normal physiological range in accordance with their age and gender, the elevated serum levels of creatine kinase (CK) and creatine kinase myocardial band (CK-MB) was determined in 21% of the cases (n=12). The pH value of venous blood gas of a case, in whom the elevated levels of CK-MB and CK were found to be directly proportional, was determined as 7.16. The level of troponin-I, electrocardiogram (ECG) findings, hemogram and coagulation parameters were also within the normal physiological range in accordance with their age and gender. The mean venous blood glucose levels were found as 120 ± 29 mg/dL (min: 78 mg/dL, max: 214 mg/dL), and a reverse correlation was detected between the hyperglysemic conditions of the cases and GCS scores on arrival. Of the bonsai intoxication cases, 60 had been treated with hydration therapy (0.9% NaCl solution, 15cc/min, 2000 cc), one was intubated by using midazolam, and monitored and treated in the emergency service.
Conclusion: Patients with different states of consciousness have been frequently encountered in the emergency service. This condition may depend on various factors such as alcohol, certain endocrine diseases (hypo-hyperglycemia, thyrotoxicosis, etc.), trauma, infections (central nervous system infections, sepsis, etc.), cerebrovascular disorders and intoxication. By considering the elevated synthetic cannabinoid (SC) abuse among the adolescents recently, the use of CB should be kept in mind for the pre-diagnosis of the juvenile patients who were brought to the emergency service with loss of consciousness.
Citations in the library
Cites 3
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