Social pain: A systematic review on interventions
Brandon M. Brooks, Francisco J. Cordero, Stephen L. Alchermes, Bradley M. Brooks
F1000Research January 10, 2025 DOI: 10.12688/f1000research.159561.1 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Systematic review Randomized Open-label Peer reviewed |
|---|---|
| Interventions | Acetaminophen open-label placebo mindfulness training psilocybin forgiveness |
| Keywords | Psychological intervention Systematic review Randomized controlled trial Psychotherapist Medline Physical therapy |
| Citations | 3 |
| Key findings | Acetaminophen, deceptive and open-label placebos, mindfulness training, and psilocybin reduce social pain, and combining acetaminophen with forgiveness yields superior results. |
Abstract
Social pain is emotional distress caused by harm or threat to social connections that results in social exclusion, rejection, or loss. Social Pain is also a potentiator of physical pain. Supportive social relationships are widely recognized for their impact on maintaining health and well-being. The Passion of Jesus Christ serves as a quintessential example of social pain (i.e., desertion, betrayal, denial) potentiating physical pain (i.e., beatings, Crown of Thorns, crucifixion). Christ opts to forgive. Although forgiveness is one solution to reduce social pain, other interventions exist. This review seeks to identify and summarize interventions associated with reducing social pain. We conducted a systematic review using Medline (PubMed), Google Scholar, and Cochrane CENTRAL to identify relevant articles. Results: The database searches produced 548 articles. Fourteen randomized controlled trials (RCTs) were included in this systematic review. Acetaminophen, both deceptive and open-label placebos, mindfulness training, and psilocybin were found to reduce social pain. Of note, the combination of acetaminophen and forgiveness yielded superior results compared to either acetaminophen or forgiveness alone. Pharmacological interventions operate on the premise that the neural pathways responsible for physical pain also play a role in social pain. Both pharmacological and non-pharmacological interventions are available for reducing social pain.
Citations in the library
Cites 5
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- Effects of serotonin 2A/1A receptor stimulation on social exclusion processing Proceedings of the National Academy of Sciences April 18, 2016
- Ruminative and mindful self-focused attention in borderline personality disorder. Personality Disorders Theory Research and Treatment October 11, 2011
- Open-Label Placebo: Reflections on a Research Agenda. Perspectives in biology and medicine 2018
- Effects of brief mindfulness and loving-kindness meditation inductions on emotional and behavioral responses to social rejection among individuals with high borderline personality traits. Behaviour Research and Therapy 2018