Teratogenic effects of Mimosa tenuiflora in a rat model and possible role of N-methyl- and N,N-dimethyltryptamine.
Dale R. Gardner, Franklin Riet-Correa, Danilo Lemos, Kevin Welch, James Pfister, Kip E. Panter
Journal of agricultural and food chemistry July 30, 2014 DOI: 10.1021/jf5005176 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Bioassay and fractionation study in pregnant rats Peer reviewed |
|---|---|
| Population | Pregnant rats and their pups |
| Interventions | N-methyltryptamine N N-dimethyltryptamine |
| Topics | 5-MeO-DMT DMT |
| Key points | Pups born to pregnant rats fed M. tenuiflora plant material, methanol extracts, alkaloid extracts, or purified N-methyltryptamines had a higher incidence of soft tissue cleft palate and skeletal malformations than control pups, indicating these fractions contain teratogenic compounds. |
Abstract
Mimosa tenuiflora is a shrub/tree found in northeastern Brazil sometimes eaten by livestock and believed to be responsible for malformations observed in many animals from that region. The teratogenic compounds in M. tenuiflora are not known. This study used pregnant rats fed M. tenuiflora and components therefrom for bioassay and fractionation of possible teratogenic compounds. Rat pups were examined for cranial-facial defects and skeletal malformations. Experimental diets included M. tenuiflora leaf and seed material, extracts of leaf and seed, alkaloid extracts of leaf and seed, and N-methyltryptamine and N,N-dimethyltryptamine. Pups from mothers who received M. tenuiflora plant material, methanol extracts, alkaloid extracts, and purified N-methyltryptamines had a higher incidence of soft tissue cleft palate and skeletal malformations. Results are summarized as to the frequency of observed cleft palate and other noted malformations for each diet versus control.
Comparable studies
Other preclinical and animal studies on 5-MeO-DMT, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Psychedelic N,N-dimethyltryptamine and 5-methoxy-N,N-dimethyltryptamine modulate innate and adaptive inflammatory responses through the sigma-1 receptor of human monocyte-derived dendritic cells. Human primary monocyte-derived dendritic cells | 2014 | In vitro study | |
| Effects of N,N-Dimethyltryptamine on Rat Behaviors Relevant to Anxiety and Depression Adult male Sprague-Dawley rats | 2018 | Experimental study | |
| Hallucinogen-like actions of 5-methoxy-N,N-diisopropyltryptamine in mice and rats. Mice and rats | 2006 | Preclinical study | |
| Agonist Properties of N,N-Dimethyltryptamine at Serotonin 5-HT2A and 5-HT2C Receptors Rats and transfected fibroblasts | 1998 | Experimental study | |
| Subtypes of the 5-HT receptor mediating the behavioural responses to 5-methoxy-N,N-dimethyltryptamine in the rat Intact rats and rats depleted of monoamines with reserpine | 1985 | Experimental study |
Citations in the library
Cited by 5
- Neuropharmacology of N,N-dimethyltryptamine Brain Research Bulletin April 30, 2016
- Ayahuasca: Psychological and Physiologic Effects, Pharmacology and Potential Uses in Addiction and Mental Illness Current Neuropharmacology March 2, 2018
- Toxicology and Analysis of Psychoactive Tryptamines International Journal of Molecular Sciences December 4, 2020
- Unraveling the metabolomic profile and acute toxicity of ethanolic extract from Mimosa tenuiflora (Willd.) Poir. root bark. Toxicon October 1, 2024
- The changing outlook of psychedelic drugs: The importance of risk assessment and occupational exposure limits Journal of Applied Toxicology August 30, 2023
Cites 3
- Application of analytical methods for the structural characterization and purity assessment of N,N-dimethyltryptamine, a potent psychedelic agent isolated from Mimosa tenuiflora inner barks Microchemical Journal April 5, 2012
- Characterization of the synthesis of N,N‐dimethyltryptamine by reductive amination using gas chromatography ion trap mass spectrometry Drug Testing and Analysis July 1, 2010
- Alkaloid profiles of Mimosa tenuiflora and associated methods of analysis. CABI eBooks 2011