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Variation in the accumulation levels of N,N-dimethyltryptamine in micropropagated trees and in in vitro cultures of Mimosa tenuiflora

María del Pilar Nicasio, María Luisa Villarreal, FranÇoise Gillet, Lamine Bensaddek, Marc-André Fliniaux

Natural Product Research 2005 DOI: 10.1080/14786410410001658860 (opens in new tab)

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Study at a glance

AI-extracted from the abstract
Characteristics Observational study Peer reviewed
Population Mimosa tenuiflora trees and in vitro cultures (plantlets and calluses)
Topics 5-MeO-DMT DMT
Citations 16
Key findings DMT accumulation in Mimosa tenuiflora varies by organ, season, and culture type, with bark showing the highest concentration (0.33% dry weight) and calluses losing DMT over successive subcultures.

Abstract

The present article reports the accumulation of N,N-dimethyltryptamine and its metabolic precursors (tryptophan, tryptamine) in different organs of micropropagated Mimosa tenuiflora trees (leaves, flowers and bark) subjected to seasonal variations (January and June), as well as in in vitro cultures (plantlets and calluses) of this plant species. The accumulation of all the tested compounds varied according to the organ, the month of collection, and age of the plant material. In all cases, the neurotoxic compound N,N-dimethyltryptamine (DMT) was detected with the lowest concentration 0.01% dry weight (DW) in flowers, and the highest 0.33% DW in bark. For the in vitro cultures, DMT was present in high yields in plantlets (0.1-0.2% DW), while in calluses this compound was initially detected but its concentration decreased significantly in the subsequent subcultures.

Comparable studies

Other observational and cohort studies on 5-MeO-DMT, most cited first.

Study Year Design Participants
A single inhalation of vapor from dried toad secretion containing 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) in a naturalistic setting is related to sustained enhancement of satisfaction with life, mindfulness-related capacities, and a decrement of psychopathological symptoms. Volunteers who inhaled vapor from dried toad secretion at several European locations 2019 Observational cohort n = 42
Intensity of Mystical Experiences Occasioned by 5-MeO-DMT and Comparison With a Prior Psilocybin Study Individuals at a psychospiritual retreat in Mexico 2018 Observational cohort n = 20
Neural and subjective effects of inhaled N,N-dimethyltryptamine in natural settings. Healthy and experienced participants 2021 Observational field study n = 35
A Phase 1, Dose-Ranging Study to Assess Safety and Psychoactive Effects of a Vaporized 5-Methoxy-N, N-Dimethyltryptamine Formulation (GH001) in Healthy Volunteers. Healthy volunteers 2021 Prospective dose-finding study n = 22
Open-label study of consecutive ibogaine and 5-MeO-DMT assisted-therapy for trauma-exposed male Special Operations Forces Veterans: prospective data from a clinical program in Mexico. Trauma-exposed Special Operations Forces Veterans 2023 Prospective clinical program evaluation n = 86

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