Schizophrenia and hallucinogen persisting perception disorder: A clinical investigation.
Shaul Lev-Ran, Daniel Feingold, Dmitri Rudinski, Stefan Katz, Lerner G Arturo
American Journal on Addictions April 2015 DOI: 10.1111/ajad.12204 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Observational comparative study Peer reviewed |
|---|---|
| Sample size | 80 |
| Population | People with schizophrenia and prior LSD use, divided into those with hallucinogen persisting perception disorder (n=37) and those without (n=43) |
| Key findings | Patients with schizophrenia who developed hallucinogen persisting perception disorder scored lower on general psychopathology and negative symptoms than those who did not, while positive symptom scores and socio-demographic characteristics were similar between groups. The authors suggest that this subgroup presents with less severe psychopathology despite persistent perceptual disturbances. |
Abstract
We compared characteristics of schizophrenia patients with prior LSD use who developed hallucinogen persisting perception disorder (SCH+HPPD) with those who did not (SCH-HPPD). Data were collected for 37 subjects in the SCH+HPPD group and 43 subjects in the SCH-HPPD group. Socio-demographics and positive symptom scores were similar between groups. Individuals in the SCHIZO+HPPD group scored lower on general psychopathology and negative symptoms scores. Individuals with schizophrenia and HPPD present with less severe psychopathology, despite persistent perceptual disturbances. Our findings highlight the importance of further research into this subset of patients.
Citations in the library
Cited by 7
- Hallucinogen Persisting Perception Disorder: Etiology, Clinical Features, and Therapeutic Perspectives Brain Sciences March 16, 2018
- The “Endless Trip” among the NPS Users: Psychopathology and Psychopharmacology in the Hallucinogen-Persisting Perception Disorder. A Systematic Review Frontiers in Psychiatry November 20, 2017
- Reconsidering evidence for psychedelic-induced psychosis: an overview of reviews, a systematic review, and meta-analysis of human studies. Molecular Psychiatry March 1, 2025
- Hallucinogen persisting perception disorder: A literature review and three case reports Journal of Addictive Diseases October 2, 2018
- Hallucinogen persisting perceptual disorder: a scoping review covering frequency, risk factors, prevention, and treatment Expert Opinion on Drug Safety April 15, 2022
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