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[Hyponatremia-induced life-threatening cerebral edema after ecstasy use].

S Baumann, T Becher, D Frambach, H Wenz, T Kirschning, M Borggrefe, S Rapp, I Akin

Medizinische Klinik, Intensivmedizin und Notfallmedizin September 2016 DOI: 10.1007/s00063-015-0099-7 (opens in new tab)

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Study at a glance

AI-extracted from the abstract
Characteristics Case report Peer reviewed
Sample size 2
Population Young adults who consumed ecstasy
Intervention Ecstasy
Topics MDMA
Keywords Neurotransmitter Pulmonary edema Street drugs Young adult
Key findings Two young adults developed cerebral edema due to hyponatremia after ecstasy consumption; one recovered without sequelae and one died. The authors state that severe symptomatic hyponatremia after ecstasy use is described in the literature with partially fatal outcomes, and they recommend early, consistent sodium monitoring and interdisciplinary treatment decisions.

Abstract

Ecstasy, a psychoactive amphetamine derivative, is a popular party drug. We report the cases of 2 young adults who developed cerebral edema due to hyponatremia. One patient was released from the hospital without any sequelae, whereas the second patient died due to cerebral edema. Severe cases of symptomatic hyponatremia after ecstasy consumption are described in the literature with partially fatal clinical outcomes. Thus, physicians should be aware of early and consequent control of the sodium and choose an interdisciplinary treatment decision.

Comparable studies

Other case reports and case series on MDMA, most cited first.

Study Year Design Participants
'Eve' and 'Ecstasy'. A report of five deaths associated with the use of MDEA and MDMA Individuals whose deaths were associated with MDMA or MDEA use 1987 Case series n = 5
Pathology of deaths associated with "ecstasy" and "eve" misuse. Young white men aged 20 to 25 who died after using ring-substituted amphetamines (MDMA... 1996 Case series n = 7
'Eve' and 'Ecstasy' Individuals who died after using MDMA or MDEA 1987 Case series n = 5
A Method of Conducting Therapeutic Sessions with MDMA Clients with clear therapeutic purpose, excluding those with serious functional... 1998 Case study n = 2
Diversity of Psychopathology Associated with use of 3,4-Methylenedioxymethamphetamine (‘Ecstasy’) Psychiatric patients presenting between 1990 and 1992 whose symptoms developed in the... 1994 Case series n = 13

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