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Matters arising: Methodological concerns and interpretative limitations of assessing subjective effects of ketamine

Ramūnas Janavičius

npj Mental Health Research September 22, 2026 DOI: 10.1038/s44184-026-00240-3 (opens in new tab)

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AI-extracted from the abstract
Characteristics Peer reviewed
Topics Esketamine Ketamine

Abstract

The letter addresses critical issues in the methodology and conclusions of the meta-analysis, including inconsistencies in study design, methodological flaws in comparing correlation coefficients, and discrepancies in reported results and their interpretation. It contributes significantly to the ongoing discussion on psychedelic-assisted therapies and highlights the need for more standardized methodologies in future research.

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