Matters arising: Methodological concerns and interpretative limitations of assessing subjective effects of ketamine
Ramūnas Janavičius
npj Mental Health Research September 22, 2026 DOI: 10.1038/s44184-026-00240-3 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Peer reviewed |
|---|---|
| Topics | Esketamine Ketamine |
Abstract
The letter addresses critical issues in the methodology and conclusions of the meta-analysis, including inconsistencies in study design, methodological flaws in comparing correlation coefficients, and discrepancies in reported results and their interpretation. It contributes significantly to the ongoing discussion on psychedelic-assisted therapies and highlights the need for more standardized methodologies in future research.
Citations in the library
Cites 8
- Ketamine Assisted Psychotherapy (KAP): Patient Demographics, Clinical Data and Outcomes in Three Large Practices Administering Ketamine with Psychotherapy Journal of Psychoactive Drugs March 15, 2019
- Ketamine and psychotherapy for the treatment of psychiatric disorders: systematic review BJPsych Open May 1, 2023
- A unified model of ketamine's dissociative and psychedelic properties. Journal of Psychopharmacology December 17, 2022
- Toward Synergies of Ketamine and Psychotherapy Frontiers in Psychology March 25, 2022
- The Montreal model: an integrative biomedical-psychedelic approach to ketamine for severe treatment-resistant depression Frontiers in Psychiatry September 19, 2023
and 3 more in the library