Resveratrol plays Neuroprotective role on ketamine-induced schizophrenia-like behaviors and oxidative damage in mice.
Alireza Farkhakfar, Shahin Hassanpour, Morteza Zendehdel
Neuroscience Letters August 14, 2023 DOI: 10.1016/j.neulet.2023.137436 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Controlled animal experiment Peer reviewed |
|---|---|
| Sample size | 24 |
| Population | Male mice |
| Interventions | Resveratrol Ketamine |
| Dose | resveratrol 80 mg/kg; ketamine 20 mg/kg |
| Duration | Resveratrol for 30 days; ketamine injected from days 16 to 30 |
| Measures | object recognition test, tail suspension test, forced swimming test, open field test, malondialdehyde (MDA), glutathione peroxidase (GPx), superoxide dismutase (SOD), catalase (CAT) |
| Topics | Esketamine Ketamine |
| Key findings | Ketamine produced schizophrenia-like behavioral deficits and oxidative brain damage in mice, and resveratrol pretreatment reduced these effects: it improved body weight, open field crossings, immobility times, and memory, and reversed ketamine-induced rises in MDA and falls in SOD, GPx, and CAT. The authors suggest resveratrol has neuroprotective effects. |
Abstract
This study aimed to determine effects of the resveratrol on ketamine-induced schizophrenia-like behaviors and oxidative damage in mice. Twenty-four male mice were allocated into four experimental groups as control, ketamine (20mg/kg), resveratrol (80mg/kg) and co-administration of the ketamine (20mg/kg) + resveratrol (80mg/kg). Mice were received resveratrol for 30 days and ketamine was used for an animal model of schizophrenia and was injected from days 16 to 30 of the study. After the drug administration was finished, schizophrenia-like behaviors were evaluated using object recognition test, tail suspension test, forced swimming test and open field test and brain malondialdehyde, glutathione peroxidase, superoxide dismutase and catalase levels were determined. According to the results, ketamine treatment significantly decreased body weight and pretreatment with resveratrol elevated body weight compared to ketamine group (P<0.05). Ketamine treatment significantly decreased number of the cross in open field test and pretreatment with resveratrol improved i (P<0.05). Immobility time in tail suspension and forced swimming tests increased in mice treated with ketamine (P<0.05). Pretreatment with resveratrol diminished immobility time compared to ketamine group (P<0.05). Ketamine significantly decreased memory deficits while pretreatment with resveratrol significantly reduced the memory deficits induced by ketamine (P<0.05). Brain MDA increased in both cortical and sub-cortical area in ketamine treated mice while pretreatment with resveratrol decreased ketamine-induced elevation in MDA (P<0.05). Ketamine significantly decreased brain SOD, GPx and CAT levels while pretreatment with resveratrol improved SOD, GPx and CAT levels (P<0.05). Findings suggested resveratrol has neuroprotective effects against ketamine-induced behavioral deficits and oxidative damages.
Comparable studies
Other preclinical and animal studies on ketamine, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists Rats | 2010 | Observational study | |
| Activation of Glutamatergic Neurotransmission by Ketamine: A Novel Step in the Pathway from NMDA Receptor Blockade to Dopaminergic and Cognitive Disruptions Associated with the Prefrontal Cortex Conscious rats | 1997 | Dose-response study with microdialysis and behavioral testing | |
| NMDAR inhibition-independent antidepressant actions of ketamine metabolites Mice | 2016 | Preclinical study | |
| The dissociative anaesthetics, ketamine and phencyclidine, selectively reduce excitation of central mammalian neurones by N‐methyl‐aspartate Spinal neurons in decerebrate or pentobarbitone-anaesthetized cats and rats | 1983 | Experimental study | |
| R-ketamine: a rapid-onset and sustained antidepressant without psychotomimetic side effects Mice | 2015 | Experimental study |
Citations in the library
Cited by 3
- Sigma-1 Receptor Activation by Fluvoxamine Ameliorates ER Stress, Synaptic Dysfunction and Behavioral Deficits in a Ketamine Model of Schizophrenia. Journal of Neuroimmune Pharmacology July 25, 2025
- Effects of association between resveratrol and ketamine on behavioral and biochemical analysis in mice. Journal of Neural Transmission August 1, 2024
- Chlorogenic Acid Attenuates Schizophrenia-Like Behavioral Deficits and Neuroinflammation in a Ketamine-Induced Mouse Model
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