Korean meditation music suppressed relapse to methamphetamine in rats.
Sun-Mo Yun, Soo-Min Lee, Mi Seon Kim, Sang Nam Lee, B. Lee
Neuroscience Letters November 8, 2019 DOI: 10.1016/j.neulet.2019.134620 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Preclinical animal study Peer reviewed |
|---|---|
| Population | Male Sprague-Dawley rats self-administering methamphetamine |
| Interventions | Meditation music by Young-Dong Kim control music by Jeff Beck methamphetamine GABAA and GABAB receptor antagonists |
| Dose | 0.1 mg/kg methamphetamine |
| Duration | 3 weeks of self-administration training, 1 week of extinction, reinstatement test the next day |
| Measures | active lever responding, immunofluorescence for c-Fos expression |
| Topics | Meditation |
| Key points | Meditation music by Young-Dong Kim, but not control music by Jeff Beck, reduced active lever responding during methamphetamine reinstatement in rats; the effect was blocked by GABAA and GABAB receptor antagonists, and nucleus accumbens c-Fos expression paralleled the behavioral results. The authors suggest this music may help prevent reinstatement of methamphetamine-seeking during abstinence. |
Abstract
Objective: Methamphetamine is a drug abused worldwide. Even though its abuse is a serious problem in many countries, there are few safe and effective therapies to treat addiction. In a previous study, music therapy attenuated relapse to morphine. Based on the study, we investigated whether music therapy suppresses the reinstatement of methamphetamine self-administration behavior.
Methods: Male Sprague-Dawley rats were trained to intravenously self-administer methamphetamine (0.1 mg/kg) using a fixed ratio 1 schedule in a daily 2 h session. Following 3 weeks of training, rats who had established a stable daily intake were subjected to extinction for 1 week. On the next day, priming injection was performed to induce reinstatement. Music therapy was played twice daily during the extinction period and immediately before the test session. In the second experiment, the selective GABAA and GABAB receptor antagonists were treated prior to the last music therapy to investigate a possible neuronal mechanism. Immunofluorescence was performed to immunohistochemically examine the behavioral effects.
Results: The meditation music by Young-Dong Kim but not the control music by Jeff Beck reduced active lever responding during the reinstatement session. And the effects of music therapy were blocked by GABA receptors antagonists. Also, immunofluorescence showed the pattern of c-Fos expression in the nucleus accumbens paralleled the behavioral results.
Conclusion: Results of the present study suggest that meditation music by Young-Dong Kim can be a useful therapy to prevent the reinstatement of methamphetamine addiction during abstinence.
Comparable studies
Other preclinical and animal studies on meditation, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Meditation, Not Information? A Survey Experiment Probing the Effects of Meditation Practice on Affective Polarization and Pro-Environmentalism US adults surveyed online, including self-identified Republicans and Democrats | 2025 | Preregistered survey experiment | n = 500 |
| Changes in white matter in mice resulting from low-frequency brain stimulation. Mice | 2018 | Preclinical experimental study | |
| Modeling the Effects of Yoga on the Progression of Alzheimer's Disease in a Dish. Cultured basal forebrain cholinergic neurons exposed to oligomeric amyloid beta (OAβI-42) | 2018 | In vitro study | |
| Rhythmic brain stimulation reduces anxiety-related behavior in a mouse model based on meditation training. Mice | 2017 | Randomized controlled trial |