Subcortical Anatomy of the Default Mode Network: a functional and structural connectivity study
Pedro Nascimento Alves, Chris Foulon, Vyacheslav Karolis, Danilo Bzdok, Daniel S. Margulies, Emmanuelle Volle, Michel Thiebaut De Schotten
Study at a glance
AI-extracted from the abstract| Characteristics | Theoretical or philosophical paper |
|---|---|
| Topics | Default mode network |
| Key points | The authors propose a more comprehensive neuroanatomical model of the default-mode network that includes the basal forebrain, anterior and mediodorsal thalamic nuclei, and cholinergic nuclei. Tractography analyses indicated that the thalamus and basal forebrain had high node degree and centrality within the network, which the authors argue reconciles neuroimaging with neuropathological findings and may help identify a conserved DMN homologue in other mammals. |
Abstract
Abstract: Most existing research into the default-mode network (DMN) has taken a corticocentric approach. Despite the resemblance of the DMN with the unitary model of the limbic system, the anatomy and contribution of subcortical structures to the network may be underappreciated due to methods limitation. Here, we propose a new and more comprehensive neuroanatomical model of the DMN including the basal forebrain and anterior and mediodorsal thalamic nuclei and cholinergic nuclei. This has been achieved by considering functional territories during interindividual brain alignment. Additionally, tractography of diffusion-weighted imaging was employed to explore the structural connectivity of the DMN and revealed that the thalamus and basal forebrain had high importance in term of values of node degree and centrality in the network. The contribution of these neurochemically diverse brain nuclei reconciles previous neuroimaging with neuropathological findings in diseased brain and offers the potential for identifying a conserved homologue of the DMN in other mammalian species.
Comparable studies
Other theoretical and historical papers on default mode network, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| The entropic brain: a theory of conscious states informed by neuroimaging research with psychedelic drugs | 2014 | Theoretical or philosophical paper | |
| The default mode network in cognition: a topographical perspective | 2021 | Theoretical or philosophical paper | |
| The default mode network: where the idiosyncratic self meets the shared social world | 2021 | Theoretical or philosophical paper | |
| The default-mode, ego-functions and free-energy: a neurobiological account of Freudian ideas | 2010 | Theoretical or philosophical paper | |
| Cooperation between the default mode network and the frontal–parietal network in the production of an internal train of thought | 2011 | Theoretical or philosophical paper |
Citations in the library
Cites 5
- A default mode of brain function Proceedings of the National Academy of Sciences January 16, 2001
- Patterns of Brain Activity Supporting Autobiographical Memory, Prospection, and Theory of Mind, and Their Relationship to the Default Mode Network Journal of Cognitive Neuroscience July 6, 2009
- Rat brains also have a default mode network Proceedings of the National Academy of Sciences February 21, 2012
- Salience and default mode network dysregulation in chronic cocaine users predict treatment outcome Brain May 1, 2017
- Failure to deactivate in the prefrontal cortex in schizophrenia: dysfunction of the default mode network? Psychological Medicine August 1, 2008