Effects of cannabis use on antidepressant treatment response to repetitive transcranial magnetic stimulation and ketamine
Mohammad Ali Shenasa, Houtan Totonchi Afshar, Eric A. Miller, Em Ellerman-Tayag, Jyoti Mishra, Dhakshin Ramanathan
medRxiv Preprint Server June 28, 2023 preprint DOI: 10.1101/2023.06.28.23291446 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Theoretical or philosophical paper |
|---|---|
| Topics | Cannabis Esketamine Ketamine |
| Keywords | Cannabis use Substance use Depression treatment Depression therapy Antidepressant therapy Brain therapies Ketamine therapy Rtms Transcranial magnetic stimulation Neuromodulation Mental health Well-being |
| Key points | Proposes that cannabis use may moderate the antidepressant effects of ketamine and rTMS by impairing synaptic plasticity via CB1 receptor activation. |
Abstract
Background The antidepressant effects of ketamine and repetitive transcranial magnetic stimulation (rTMS) are hypothesized to rely on mechanisms of long-term-potentiation and synaptic plasticity. Cannabis, via activation of CB1 receptors has been shown to impair synaptic plasticity, suggesting that cannabis use might moderate the antidepressant effects of ketamine and/or rTMS.
Comparable studies
Other theoretical and historical papers on cannabis, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Delta-8, Delta-10, HHC, THC-O, THCP, and THCV: What Should We Call These Products? | 2023 | Theoretical or philosophical paper | |
| Model Psychoses Induced by LSD-25 in Normals | 1956 | Historical analysis | |
| Is there a specific ‘cannabis psychosis’? | 2004 | Theoretical or philosophical paper | |
| Peak-experience and the entheogenic use of cannabis in world religions | 2021 | Theoretical or philosophical paper | |
| Out of Harm's Way?: Illicit Drug Use, Medicalization and the Law | 2003 | Theoretical or philosophical paper |
Citations in the library
Cites 4
- Mechanisms of Ketamine Action as an Antidepressant Molecular Psychiatry March 13, 2018
- EFFICACY AND SAFETY OF RACEMIC KETAMINE AND ESKETAMINE FOR DEPRESSION: A SYSTEMATIC REVIEW AND META-ANALYSIS Expert Opinion on Drug Safety March 9, 2022
- Bridging rapid and sustained antidepressant effects of ketamine Trends in molecular medicine March 1, 2023
- Impairment of Synaptic Plasticity by Cannabis, Δ9-THC, and Synthetic Cannabinoids. Cold Spring Harbor perspectives in medicine May 3, 2021