Contribution of default mode network to game and delayed-response task performance: Power and connectivity analyses of theta oscillation in the monkey.
Tohru Kodama, Takashi Kojima, Yoshiko Honda, Takayuki Hosokawa, Akihiro Karashima, Masataka Watanabe
Neuroscience Letters September 25, 2023 DOI: 10.1016/j.neulet.2023.137465 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Electrophysiological study in a nonhuman primate Peer reviewed |
|---|---|
| Population | Monkey |
| Measures | EEG theta power, Granger causality analysis |
| Topics | Default mode network |
| Keywords | Cognitive control Delayed-response Granger causality Theta oscillation Video game |
| Key points | Default mode and executive networks worked cooperatively in both a competitive video game and a delayed-response task. Theta power increased above rest in all three recorded areas during the video game but not the delayed-response task, possibly reflecting higher cognitive demand. Theta-band information flow was directed more toward the anterior default mode network than away from it in both tasks. |
Abstract
Neuroimaging studies have demonstrated the presence of a default mode network (DMN) which shows greater activity during rest, and an executive network (EN) which is activated during cognitive tasks. DMN and EN are thought to have competing functions. However, recent studies reported that the two networks show coactivation during some cognitive tasks. To clarify how DMN works and how DMN interacts with EN for cognitive control, we recorded EEG activities in the medial prefrontal (anterior DMN: aDMN), posterior cingulate/precuneus (posterior DMN: pDMN), and lateral prefrontal (EN) areas in the monkey. As cognitive tasks, we employed a monkey-monkey competitive video game (GAME) and a delayed-response (DR) task. We focused on theta oscillation because of its importance in cognitive control. We also examined theta band connectivity among the three network areas using the Granger causality analysis. DMN and EN were found to work cooperatively in both tasks. In all the three network areas, we found GAME-task-related, but no DR-task-related, increase in theta power from the resting level, maybe because of the higher cognitive demand associated with the GAME task performance. The information flow conveyed by the theta oscillation was directed more to aDMN than from aDMN for both tasks. The GAME-task-related increase in theta power in aDMN is supposed to be supported by more information flow conveyed by the theta oscillation from EN and pDMN.
Comparable studies
Other preclinical and animal studies on default mode network, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Rat brains also have a default mode network Rats | 2012 | Observational study | |
| Large-scale topology and the default mode network in the mouse connectome Mouse brain | 2014 | Observational study | |
| Hippocampal Sharp-Wave Ripples Influence Selective Activation of the Default Mode Network Anesthetized monkeys | 2016 | Observational study | |
| Psilocybin-induced default mode network hypoconnectivity is blunted in alcohol-dependent rats Healthy rats and a rat model of alcohol relapse | 2023 | Randomized, placebo-controlled crossover pharmaco-fMRI study | |
| Altered functional connectivity within the default mode network in two animal models with opposing episodic memories Rats (control, LPS-challenged, and footshock-exposed groups) | 2018 | Animal model study |
Citations in the library
Cites 4
- A default mode of brain function Proceedings of the National Academy of Sciences January 16, 2001
- On the relationship between the “default mode network” and the “social brain” Frontiers in Human Neuroscience 2012
- Fractionating the Default Mode Network: Distinct Contributions of the Ventral and Dorsal Posterior Cingulate Cortex to Cognitive Control Journal of Neuroscience March 2, 2011
- Frontal theta EEG activity correlates negatively with the default mode network in resting state International Journal of Psychophysiology July 13, 2007