Functional changes of default mode network and structural alterations of gray matter in patients with irritable bowel syndrome: a meta-analysis of whole-brain studies.
Mengqi Zhao, Zeqi Hao, Mengting Li, Hongyu Xi, Su Hu, Jianjie Wen, Yanyan Gao, Collins Opoku Antwi, Xize Jia, Yang Yu, Jun Ren
Frontiers in Neuroscience 2023 DOI: 10.3389/fnins.2023.1236069 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Meta-analysis Peer reviewed |
|---|---|
| Sample size | 424 |
| Population | Adults with irritable bowel syndrome (194 patients) and healthy controls (230), drawn from 12 studies |
| Topics | Default mode network |
| Keywords | Functional connectivity Irritable bowel syndrome Meta-analysis Voxel-based morphometry |
| Key findings | Pooled across 12 studies, IBS patients showed abnormal resting-state functional connectivity in regions including the left inferior parietal gyrus, right precuneus, right amygdala, and left hippocampus, plus gray matter alterations in areas such as the fusiform gyrus and right putamen, compared with healthy controls. The left middle frontal gyrus, left orbital inferior frontal gyrus, and right putamen showed both functional and structural changes. The authors state these results may contribute to understanding IBS pathophysiology. |
Abstract
Irritable bowel syndrome (IBS) is a brain-gut disorder with high global prevalence, resulting from abnormalities in brain connectivity of the default mode network and aberrant changes in gray matter (GM). However, the findings of previous studies about IBS were divergent. Therefore, we conducted a meta-analysis to identify common functional and structural alterations in IBS patients. Altogether, we identified 12 studies involving 194 IBS patients and 230 healthy controls (HCs) from six databases using whole-brain resting state functional connectivity (rs-FC) and voxel-based morphometry. Anisotropic effect-size signed differential mapping (AES-SDM) was used to identify abnormal functional and structural changes as well as the overlap brain regions between dysconnectivity and GM alterations. Findings indicated that, compared with HCs, IBS patients showed abnormal rs-FC in left inferior parietal gyrus, left lingual gyrus, right angular gyrus, right precuneus, right amygdala, right median cingulate cortex, and left hippocampus. Altered GM was detected in the fusiform gyrus, left triangular inferior frontal gyrus (IFG), right superior marginal gyrus, left anterior cingulate gyrus, left rectus, left orbital IFG, right triangular IFG, right putamen, left superior parietal gyrus and right precuneus. Besides, multimodal meta-analysis identified left middle frontal gyrus, left orbital IFG, and right putamen as the overlapped regions. Our results confirm that IBS patients have abnormal alterations in rs-FC and GM, and reveal brain regions with both functional and structural alterations. These results may contribute to understanding the underlying pathophysiology of IBS. https://www.crd.york.ac.uk/prospero, identifier CRD42022351342.
Comparable studies
Other systematic reviews and meta-analyses on default mode network, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| The wandering brain: Meta-analysis of functional neuroimaging studies of mind-wandering and related spontaneous thought processes | 2015 | Meta-analysis | |
| Investigating the Functional Heterogeneity of the Default Mode Network Using Coordinate-Based Meta-Analytic Modeling | 2009 | Meta-analysis | |
| The Default Mode Network in Healthy Individuals: A Systematic Review and Meta-Analysis Healthy individuals | 2016 | Systematic review and meta-analysis | |
| Dreaming as mind wandering: evidence from functional neuroimaging and first-person content reports. | 2013 | Systematic review with meta-analytic comparison | |
| Default Mode Network Modulation by Psychedelics: A Systematic Review Participants from included studies | 2022 | Systematic review |