Resting-state abnormalities in functional connectivity of the default mode network in migraine: A meta-analysis
Su Hu, Zeqi Hao, Meng-Ting Li, Mengqi Zhao, Jianjie Wen, Yan-Yan Gao, Qing Wang, Hong-Yu Xi, C. O. Antwi, Xize Jia, Jun Ren
Frontiers in Neuroscience March 1, 2023 DOI: 10.3389/fnins.2023.1136790 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Meta-analysis Peer reviewed |
|---|---|
| Sample size | 403 |
| Population | 204 migraine patients and 199 healthy subjects from nine resting-state fMRI studies published before July 2022 |
| Topics | Default mode network |
| Key findings | Pooling nine resting-state fMRI studies, migraine patients showed increased default mode network connectivity in regions including the right calcarine gyrus, left inferior occipital gyrus, left postcentral gyrus, right cerebellum, right parahippocampal gyrus, and right posterior cingulate gyrus, and decreased connectivity in regions including the right postcentral gyrus, left superior frontal gyrus, right superior occipital gyrus, right orbital inferior frontal gyrus, left middle occipital gyrus, left middle frontal gyrus, and left inferior frontal gyrus. The authors propose these common connectivity abnormalities may serve as a biomarker and inform migraine pathophysiology and treatment. |
Abstract
Migraine—a disabling neurological disorder, imposes a tremendous burden on societies. To reduce the economic and health toll of the disease, insight into its pathophysiological mechanism is key to improving treatment and prevention. Resting-state functional magnetic resonance imaging (rs-fMRI) studies suggest abnormal functional connectivity (FC) within the default mode network (DMN) in migraine patients. This implies that DMN connectivity change may represent a biomarker for migraine. However, the FC abnormalities appear inconsistent which hinders our understanding of the potential neuropathology. Therefore, we performed a meta-analysis of the FC within the DMN in migraine patients in the resting state to identify the common FC abnormalities. With efficient search and selection strategies, nine studies (published before July, 2022) were retrieved, containing 204 migraine patients and 199 healthy subjects. We meta-analyzed the data using the Anisotropic Effect Size version of Signed Differential Mapping (AES-SDM) method. Compared with healthy subjects, migraine patients showed increased connectivity in the right calcarine gyrus, left inferior occipital gyrus, left postcentral gyrus, right cerebellum, right parahippocampal gyrus, and right posterior cingulate gyrus, while decreased connectivity in the right postcentral gyrus, left superior frontal gyrus, right superior occipital gyrus, right orbital inferior frontal gyrus, left middle occipital gyrus, left middle frontal gyrus and left inferior frontal gyrus. These results provide a new perspective for the study of the pathophysiology of migraine and facilitate a more targeted treatment of migraine in the future.
Comparable studies
Other systematic reviews and meta-analyses on default mode network, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| The wandering brain: Meta-analysis of functional neuroimaging studies of mind-wandering and related spontaneous thought processes | 2015 | Meta-analysis | |
| Investigating the Functional Heterogeneity of the Default Mode Network Using Coordinate-Based Meta-Analytic Modeling | 2009 | Meta-analysis | |
| The Default Mode Network in Healthy Individuals: A Systematic Review and Meta-Analysis Healthy individuals | 2016 | Systematic review and meta-analysis | |
| Dreaming as mind wandering: evidence from functional neuroimaging and first-person content reports. | 2013 | Systematic review with meta-analytic comparison | |
| Default Mode Network Modulation by Psychedelics: A Systematic Review Participants from included studies | 2022 | Systematic review |
Citations in the library
Cited by 2
- Local activity alterations in autism spectrum disorder correlate with neurotransmitter properties and ketamine induced brain changes. medRxiv October 21, 2024
- Altered Neuromagnetic Activity in the Default Mode Network in Migraine and Its Subgroups (Episodic Migraine and Chronic Migraine). Journal of Integrative Neuroscience January 22, 2024