DEXTROMETHORPHAN- AN EMERGING DRUG OF ABUSE
Mayank David Raiborde, G. Kumar, P. Singh, Spriha Sharma
Journal of Pharmaceutical Negative Results October 12, 2022 DOI: 10.47750/pnr.2022.13.s06.087 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Review Peer reviewed |
|---|---|
| Intervention | Dextromethorphan |
| Key findings | The review describes dextromethorphan as an effective cough suppressant that, at maximum or overdose levels, produces hallucinogenic and psychoactive effects resembling LSD, and notes its emergence as a drug of abuse due to easy availability. It also outlines the drug's pharmacokinetics, NMDA receptor relationship, and toxicological analysis methods. |
Abstract
Dextromethorphan or DXM is an effective and harmless cough and cold suppressant available in many cold and cough preparations. At maximum dosage, it mimics hallucinogenic and psychoactive effects in human body and hence it is appealing for abuse. In this work, a detailed study of an antitussive agent i.e. Dextromethorphan which is a semi-synthetic opioid and a replacement of codeine and pholcodine in various cough linctuses has been described extensively. This review also revolves around the structured detailing of Dextromethorphan, its physical and chemical properties as well its pharmacokinetics in human body and also its effect on human brain and its relationship with NMDA receptors. This study also focuses on the emergence of Dextromethorphan as new drug of abuse due to its easy availability and as it possesses similar effects with LSD and other hallucinogens when taken in overdose in addition with the Toxicological analysis of Dextromethorphan from biological matrices using respective analytical methods.
Citations in the library
Cites 4
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