Dextromethorphan-Induced Altered Level of Consciousness in Children: A Case Series
Priyanka Pravinbhai Hotha, Rachna Gupta, Manish Narang
Current Drug Safety August 1, 2023 DOI: 10.2174/1574886317666220606145809 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Case report Peer reviewed |
|---|---|
| Sample size | 3 |
| Population | Children who developed altered consciousness after taking dextromethorphan |
| Intervention | Dextromethorphan |
| Measures | World Health Organization Uppsala Monitoring Centre causality scale |
| Topics | Altered states of consciousness |
| Key findings | Three children developed altered levels of consciousness after a first therapeutic dose of dextromethorphan syrup, becoming unresponsive to verbal commands and pain; all recovered with supportive care after the drug was stopped. The authors assessed the adverse reaction as probable or likely related to dextromethorphan and advise cautious prescribing in children. |
Abstract
Background: Dextromethorphan, a N-methyl-d-aspartate receptor antagonist, has been used as cold and cough medication. Serious adverse events with therapeutic doses of dextromethorphan are rarely observed. Here, we report three cases of altered level of consciousness in children with therapeutic dose of dextromethorphan. Case Presentation: In all three cases, children developed altered level of consciousness after taking first dose of syrup dextromethorphan. Children were unresponsive to any verbal command and pain stimuli. Medical history revealed no pre-existing comorbidities. Other systemic, cardiovascular, abdominal, respiratory and nervous system examinations were normal. All patients were hospitalised and managed with symptomatic and supportive care. Dextromethorphan was stopped. After adequate treatment, all of them recovered satisfactorily. The causality assessment was done based on the World Health Organization Uppsala Monitoring Centre causality scale and it was probable/likely in all three cases.
Conclusion: In children, altered level of consciousness could occur with therapeutic doses of dextromethorphan; hence, health care professionals should prescribe dextromethorphan with extreme caution.