Cannabis, esquizofrenia y cognición, aportes de la conectividad cerebral
Cecilia María Díaz-Soto, Guillermo Alonso Castaño Pérez, David Antonio Pineda-Salazar
Adicciones February 6, 2020 DOI: 10.20882/adicciones.1307 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Review Peer reviewed |
|---|---|
| Topics | Cannabis |
| Citations | 7 |
| Key findings | The authors argue that evidence on whether cannabis use favors neurocognition in schizophrenia patients is inconclusive, and that existing studies have methodological problems. They propose that functional connectivity research based on recent brain connectivity models could clarify the neurophysiological mechanisms of cognition in marijuana-using schizophrenia patients, noting that some studies show less cognitive deterioration in cannabis-using patients, possibly related to CBD. |
Abstract
The lack of consensus on the issue of whether the consumption of cannabis favors neurocognition among schizophrenia-diagnosed patients or not, plus methodological problems found in available evidence and the limitations of studies focused on diagnosis and treatment for positive symptoms are sufficient reason for designing new research proposals based on recent brain connectivity models. The objective of this paper is to review available literature databases, selected for neurocognition in cannabis-using schizophrenia patients and to analyze contributions made by functional connectivity studies. Cognitive impairment among schizophrenia patients is found even before the appearance of the first psychotic symptoms. Measuring cognitive function in these patients, techniques such as fMRI and EEG have found brain impairment. Furthermore, regarding schizophrenia-diagnosed patients who use cannabis, some studies have shown less deterioration among cognitive domains, which may apparently be related with one of its components (CBD). Measuring brain connectivity can be useful for clarifying neurophysiological mechanisms of cognition in marihuana-using schizophrenia patients. Cognitive decline is generalized in schizophrenia patients and is considered fundamental for disease physiopathology.
Comparable studies
Other narrative reviews on cannabis, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Causal association between cannabis and psychosis: examination of the evidence | 2004 | Review | |
| Cannabis sativa: A comprehensive ethnopharmacological review of a medicinal plant with a long history. General (historical and pharmacological review) | 2018 | Review | |
| Psychiatric effects of cannabis | 2001 | Review | |
| Beyond THC: The New Generation of Cannabinoid Designer Drugs | 2011 | Review | |
| Cannabidiol, a Cannabis sativa constituent, as an antipsychotic drug | 2006 | Review |
Citations in the library
Cited by 2
- Relação entre uso de cannabis e a esquizofrenia: uma revisão de literatura Brazilian Journal of Health Review September 21, 2023
- O uso de Cannabis como fator de risco para o desenvolvimento/progressão de quadros de Esquizofrenia: Uma revisão de literatura Research, Society and Development November 4, 2023
Cites 15
- Gone to Pot – A Review of the Association between Cannabis and Psychosis Frontiers in Psychiatry May 22, 2014
- The Impact of Cannabis Use on Cognitive Functioning in Patients With Schizophrenia: A Meta-analysis of Existing Findings and New Data in a First-Episode Sample Schizophrenia Bulletin July 25, 2010
- Modulation of effective connectivity during emotional processing by Δ9-tetrahydrocannabinol and cannabidiol The International Journal of Neuropsychopharmacology September 24, 2009
- Neurocognitive functions of heavy cannabis using schizophrenia patients European Psychiatry June 28, 2011
- Consumo de cannabis y alteraciones cognitivas en esquizofrenia y primeros episodios psicóticos Adicciones April 1, 2019
and 10 more in the library