The Relationship between Cannabis Use and Cognition in People with Bipolar Disorder: A Systematic Scoping Review
T. Jordan Walter, Nina Pocuca, Jared W Young, Mark A. Geyer, Arpi Minassian, William Perry
medRxiv April 29, 2020 preprint DOI: 10.1101/2020.04.24.20078535 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Scoping review Longitudinal |
|---|---|
| Population | People with bipolar disorder or relevant animal models, across six observational human studies |
| Topics | Cannabis |
| Citations | 1 |
| Key findings | Across six observational studies, most suggest cannabis use is not associated with significant cognitive impairment in bipolar disorder: two found better performance in some cognitive domains, three found no association, and one found worse overall cognition. The authors conclude the field's evidence is limited and call for longitudinal, experimental, and well-controlled observational studies. |
Abstract
ABSTRACT Bipolar disorder (BD) and cannabis use are highly comorbid and are each associated with cognitive impairment. It is therefore important to understand the relationship between cannabis use and cognition in people with BD, as cannabis use in BD may be associated with greater cognitive impairment. We performed a scoping review to determine how much and what is currently known in this field. We systematically searched PubMed, Embase, CINAHL, Web of Science, and PsycINFO for studies on the relationship between cannabis and cognition in people with BD or relevant animal models. Six observational human studies met inclusion criteria. Two studies found cannabis use in BD was associated with better performance in some cognitive domains, while three studies found no association. One study found cannabis use in BD was associated with worse overall cognition. Overall, most identified studies suggest cannabis use is not associated with significant cognitive impairment in BD; however, the scope of knowledge in this field is limited, and more systematic studies are clearly required. Future studies should focus on longitudinal and experimental trials, as well as well-controlled observational studies with rigorous quantification of the onset, frequency, quantity, duration, and type of cannabis use.
Comparable studies
Other narrative reviews on cannabis, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Causal association between cannabis and psychosis: examination of the evidence | 2004 | Review | |
| Cannabis sativa: A comprehensive ethnopharmacological review of a medicinal plant with a long history. General (historical and pharmacological review) | 2018 | Review | |
| Psychiatric effects of cannabis | 2001 | Review | |
| Beyond THC: The New Generation of Cannabinoid Designer Drugs | 2011 | Review | |
| Cannabidiol, a Cannabis sativa constituent, as an antipsychotic drug | 2006 | Review |
Citations in the library
Cites 4
- Individual and combined effects of acute delta-9-tetrahydrocannabinol and cannabidiol on psychotomimetic symptoms and memory function. Translational Psychiatry September 5, 2018
- Association of Cannabis With Cognitive Functioning in Adolescents and Young Adults: A Systematic Review and Meta-analysis JAMA Psychiatry June 1, 2018
- Associations between Adolescent Cannabis Use and Brain Structure in Psychosis Psychiatry Research Neuroimaging March 28, 2018
- Acute and Chronic Effects of Cannabinoids on Human Cognition-A Systematic Review. Biological Psychiatry April 1, 2016